Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth

Seung Mi Lee, Joong Shin Park, Errol R. Norwitz, Sitthysack Panyavatthanasinh, Sun Min Kim, Joonho Lee, Chan Wook Park, Byoung Jae Kim, Jong Kwan Jun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. Study Design: The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery. Results: A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins. Conclusion: In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins.

Original languageEnglish
Article numbere0154537
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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adipokines
amniotic fluid
Adipokines
fetal development
Amniotic Fluid
Fetal Development
Fetal Blood
Blood
Adiponectin
Leptin
Fluids
Plasminogen Activator Inhibitor 1
blood
adiponectin
leptin
Amniocentesis
Birth Weight
Fetus
Parturition
birth weight

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Seung Mi ; Park, Joong Shin ; Norwitz, Errol R. ; Panyavatthanasinh, Sitthysack ; Kim, Sun Min ; Lee, Joonho ; Park, Chan Wook ; Kim, Byoung Jae ; Jun, Jong Kwan. / Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth. In: PloS one. 2016 ; Vol. 11, No. 5.
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title = "Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth",
abstract = "Objective: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. Study Design: The study population included DCDA twins discordant for fetal growth (birth weight difference >10{\%}) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery. Results: A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins. Conclusion: In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins.",
author = "Lee, {Seung Mi} and Park, {Joong Shin} and Norwitz, {Errol R.} and Sitthysack Panyavatthanasinh and Kim, {Sun Min} and Joonho Lee and Park, {Chan Wook} and Kim, {Byoung Jae} and Jun, {Jong Kwan}",
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Lee, SM, Park, JS, Norwitz, ER, Panyavatthanasinh, S, Kim, SM, Lee, J, Park, CW, Kim, BJ & Jun, JK 2016, 'Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth', PloS one, vol. 11, no. 5, e0154537. https://doi.org/10.1371/journal.pone.0154537

Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth. / Lee, Seung Mi; Park, Joong Shin; Norwitz, Errol R.; Panyavatthanasinh, Sitthysack; Kim, Sun Min; Lee, Joonho; Park, Chan Wook; Kim, Byoung Jae; Jun, Jong Kwan.

In: PloS one, Vol. 11, No. 5, e0154537, 01.05.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Levels of adipokines in amniotic fluid and cord blood collected from dichorionic-diamniotic twins discordant for fetal growth

AU - Lee, Seung Mi

AU - Park, Joong Shin

AU - Norwitz, Errol R.

AU - Panyavatthanasinh, Sitthysack

AU - Kim, Sun Min

AU - Lee, Joonho

AU - Park, Chan Wook

AU - Kim, Byoung Jae

AU - Jun, Jong Kwan

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. Study Design: The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery. Results: A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins. Conclusion: In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins.

AB - Objective: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. Study Design: The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery. Results: A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins. Conclusion: In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins.

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