Lewis acid-catalyzed cascade radical addition/cyclization for the synthesis of 3-substituted isoindolin-1-one derivatives

Lianjin Zhang, Jin Bum Kim, Doook Jang

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12 Citations (Scopus)


Radical addition reactions to 2-formylbenzoate-derived hydrazones in the presence of a Lewis acid were developed. Under the reaction conditions, the resulting products were readily converted into 3-substituted isoindolin-1-one derivatives. Diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives was also established employing L-proline as a chiral auxiliary. The cascade radical addition-cyclization reaction allows direct access to 3-substituted isoindolin-1-one derivatives under tin-free conditions.

Original languageEnglish
Pages (from-to)2654-2658
Number of pages5
JournalTetrahedron Letters
Issue number16
Publication statusPublished - 2014 Apr 16


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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