Lifetime expression of stem cell markers in the uterine endometrium

Namhoon Cho, Young Kyu Park, YoungTae Kim, Hyunwon Yang, Sei Kwang Kim

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Objective: To identify stem cells in uteri from the fetal to the postmenopausal period. Design: Descriptive, controlled study. Setting: Tertiary academic medical center. Patient(s): Forty archived uterine endometrial samples. Intervention(s): Immunohistochemistry with c-kit/CD117, CD34, bcl-2, and Ki67. Main Outcome Measure(s): Immunostaining. Result(s): C-kit/CD117, CD34, bcl-2, and Ki67 were consistently expressed in the stroma of the basalis layer. Bcl-2 was restricted to the fetal uterine endometrium. Conclusion(s): By studying the immunolocalization of stem cell markers (i.e., c-kit, CD34, and bcl-2), we found that stem cells are present continuously in the uterine endometrium from the fetal period. The cells seem to be located mainly in the stroma of the basalis and to be independent of hormonal regulation to avoid cyclic shedding. A small number of latent stem cells dormant in the stroma of the basalis were found to have the potential for mesenchymal differentiation.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalFertility and Sterility
Volume81
Issue number2
DOIs
Publication statusPublished - 2004 Jan 1

Fingerprint

Endometrium
Stem Cells
Postmenopause
Uterus
Immunohistochemistry
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Cho, Namhoon ; Park, Young Kyu ; Kim, YoungTae ; Yang, Hyunwon ; Kim, Sei Kwang. / Lifetime expression of stem cell markers in the uterine endometrium. In: Fertility and Sterility. 2004 ; Vol. 81, No. 2. pp. 403-407.
@article{01aa6e953d4043f7a52838f5a4653918,
title = "Lifetime expression of stem cell markers in the uterine endometrium",
abstract = "Objective: To identify stem cells in uteri from the fetal to the postmenopausal period. Design: Descriptive, controlled study. Setting: Tertiary academic medical center. Patient(s): Forty archived uterine endometrial samples. Intervention(s): Immunohistochemistry with c-kit/CD117, CD34, bcl-2, and Ki67. Main Outcome Measure(s): Immunostaining. Result(s): C-kit/CD117, CD34, bcl-2, and Ki67 were consistently expressed in the stroma of the basalis layer. Bcl-2 was restricted to the fetal uterine endometrium. Conclusion(s): By studying the immunolocalization of stem cell markers (i.e., c-kit, CD34, and bcl-2), we found that stem cells are present continuously in the uterine endometrium from the fetal period. The cells seem to be located mainly in the stroma of the basalis and to be independent of hormonal regulation to avoid cyclic shedding. A small number of latent stem cells dormant in the stroma of the basalis were found to have the potential for mesenchymal differentiation.",
author = "Namhoon Cho and Park, {Young Kyu} and YoungTae Kim and Hyunwon Yang and Kim, {Sei Kwang}",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.fertnstert.2003.07.015",
language = "English",
volume = "81",
pages = "403--407",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "2",

}

Lifetime expression of stem cell markers in the uterine endometrium. / Cho, Namhoon; Park, Young Kyu; Kim, YoungTae; Yang, Hyunwon; Kim, Sei Kwang.

In: Fertility and Sterility, Vol. 81, No. 2, 01.01.2004, p. 403-407.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lifetime expression of stem cell markers in the uterine endometrium

AU - Cho, Namhoon

AU - Park, Young Kyu

AU - Kim, YoungTae

AU - Yang, Hyunwon

AU - Kim, Sei Kwang

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Objective: To identify stem cells in uteri from the fetal to the postmenopausal period. Design: Descriptive, controlled study. Setting: Tertiary academic medical center. Patient(s): Forty archived uterine endometrial samples. Intervention(s): Immunohistochemistry with c-kit/CD117, CD34, bcl-2, and Ki67. Main Outcome Measure(s): Immunostaining. Result(s): C-kit/CD117, CD34, bcl-2, and Ki67 were consistently expressed in the stroma of the basalis layer. Bcl-2 was restricted to the fetal uterine endometrium. Conclusion(s): By studying the immunolocalization of stem cell markers (i.e., c-kit, CD34, and bcl-2), we found that stem cells are present continuously in the uterine endometrium from the fetal period. The cells seem to be located mainly in the stroma of the basalis and to be independent of hormonal regulation to avoid cyclic shedding. A small number of latent stem cells dormant in the stroma of the basalis were found to have the potential for mesenchymal differentiation.

AB - Objective: To identify stem cells in uteri from the fetal to the postmenopausal period. Design: Descriptive, controlled study. Setting: Tertiary academic medical center. Patient(s): Forty archived uterine endometrial samples. Intervention(s): Immunohistochemistry with c-kit/CD117, CD34, bcl-2, and Ki67. Main Outcome Measure(s): Immunostaining. Result(s): C-kit/CD117, CD34, bcl-2, and Ki67 were consistently expressed in the stroma of the basalis layer. Bcl-2 was restricted to the fetal uterine endometrium. Conclusion(s): By studying the immunolocalization of stem cell markers (i.e., c-kit, CD34, and bcl-2), we found that stem cells are present continuously in the uterine endometrium from the fetal period. The cells seem to be located mainly in the stroma of the basalis and to be independent of hormonal regulation to avoid cyclic shedding. A small number of latent stem cells dormant in the stroma of the basalis were found to have the potential for mesenchymal differentiation.

UR - http://www.scopus.com/inward/record.url?scp=1242306517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242306517&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2003.07.015

DO - 10.1016/j.fertnstert.2003.07.015

M3 - Article

VL - 81

SP - 403

EP - 407

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 2

ER -