Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea

Eun Seok Kang, Yong Seok Yun, Seok Won Park, Hyeung Jin Kim, Chul Woo Ahn, Young Duk Song, Bong Soo Cha, Sungkil Lim, Kyung Rae Kim, Hyun Chul Lee

Research output: Contribution to journalArticle

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Abstract

Homeostasis model assessment of insulin resistance (HOMA-IR) is a less invasive, inexpensive, and less labor-intensive method to measure insulin resistance (IR) as compared with the glucose clamp test. The aim of this study was to evaluate the validity of HOMA-IR by comparing it with the euglycemic clamp test in determining IR. We assessed the validity of HOMA-IR by comparing it with the total glucose disposal rate measured by the 3-hour euglycemic-hyperinsulinemic clamp in subjects with type 2 diabetes (n = 47), impaired glucose tolerance (n = 21), and normal glucose tolerance (n = 22). There was a strong inverse correlation (r = -0.558; P <. 001) between the log-transformed HOMA-IR and the total glucose disposal rate. There was moderate agreement between the 2 methods in the categorization according to the IR (weighted κ = 0.294). The magnitude of the correlation coefficients was smaller in the subjects with a lower body mass index (BMI <25.0 kg/m 2, r = -0.441 vs BMI ≥25.0 kg/m2, r = -0.615; P =. 032), a lower HOMA-beta cell function (HOMA-β <60.0, r = -0.527 vs HOMA-β >60.0, r = -0.686; P =. 016), and higher fasting glucose levels (fasting glucose ≤5.66 mmol/L, r = -0.556 vs fasting glucose >5.66 mmol/L, r = -0.520; P =. 039). The limitation of the validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, a lower beta cell function, and high fasting glucose levels such as lean type 2 diabetes mellitus with insulin secretory defects.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume54
Issue number2
DOIs
Publication statusPublished - 2005 Feb 1

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Korea
Insulin Resistance
Homeostasis
Glucose
Glucose Clamp Technique
Fasting
Type 2 Diabetes Mellitus
Glucose Intolerance
Insulin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kang, Eun Seok ; Yun, Yong Seok ; Park, Seok Won ; Kim, Hyeung Jin ; Ahn, Chul Woo ; Song, Young Duk ; Cha, Bong Soo ; Lim, Sungkil ; Kim, Kyung Rae ; Lee, Hyun Chul. / Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. In: Metabolism: Clinical and Experimental. 2005 ; Vol. 54, No. 2. pp. 206-211.
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Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. / Kang, Eun Seok; Yun, Yong Seok; Park, Seok Won; Kim, Hyeung Jin; Ahn, Chul Woo; Song, Young Duk; Cha, Bong Soo; Lim, Sungkil; Kim, Kyung Rae; Lee, Hyun Chul.

In: Metabolism: Clinical and Experimental, Vol. 54, No. 2, 01.02.2005, p. 206-211.

Research output: Contribution to journalArticle

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AU - Kang, Eun Seok

AU - Yun, Yong Seok

AU - Park, Seok Won

AU - Kim, Hyeung Jin

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