Limonoids from dictamnus dasycarpus protect against glutamate-induced toxicity in primary cultured rat cortical cells

Jeong Seon Yoon, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In our previous report, four limonoids, obacunone, limonin, fraxinellone, and calodendrolide, isolated from Dictamnus dasycarpus showed significant neuroprotective activity against glutamate toxicity in primary cultured rat cortical cells. This study investigated neuroprotective mechanism of these compounds using the same in vitro culture system. These four compounds showed significant neuroprotective activity at the concentration of 0.1 μM. They effectively inhibited calcium influx and overproduction of cellular nitric oxide and reactive oxygen species accompanied by glutamate-induced neurotoxicity. In addition, these compounds significantly preserved mitochondrial membrane potential and activities of antioxidative enzymes. Our results showed that obacunone, limonin, fraxinellone, and calodendrolide significantly protect primary culture cortical cells against glutamate-induced toxicity by preserving the antioxidant defense system. These compounds might offer potential drug development candidate for various neurodegenerative diseases involved with glutamate.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalJournal of Molecular Neuroscience
Volume42
Issue number1
DOIs
Publication statusPublished - 2010 Sep 1

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

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