Lipid profiles in untreated patients with rheumatoid arthritis

YongBeom Park, Soo Kon Lee, Won Ki Lee, Chang Hee Suh, Choong Won Lee, Chan Hee Lee, Chang Ho Song, Jisoo Lee

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

Objective. To investigate lipid profiles in patients with untreated active rheumatoid arthritis (RA) and to assess the relationship of the inflammatory condition of RA with lipid profiles. Methods. Forty-two patients with RA and 42 age and sex matched healthy controls were studied. Patients with RA had not been treated with corticosteroid or disease modifying antirheumatic drugs prior to the study. Total cholesterol, triglyceride, HDL- cholesterol, LDL-cholesterol, apolipoprotein A1 (apo A1), apolipoprotein B (apo B), lipoprotein(a) [Lp(a)], and C-reactive protein (CRP) were measured in both groups. Results. The levels of apo A1 and HDL-cholesterol were significantly lower in patients than in controls (128.5 vs 151.8 mg/dl, 41.2 vs 54.9 mg/dl, respectively). The level of Lp(a) was significantly higher in patients than in controls (27.1 vs 18.0 mg/dl). The ratios of apo B/apo A1, total cholesterol/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol were significantly higher in patients than in controls (0.82 vs 0.67, 4.4 vs 3.4, 2.8 vs 1.9, respectively). CRP showed a significant correlation with apo A1 (r = -0.44, p < 0.01) and HDL-cholesterol (r = -0.35, p < 0.05). Conclusion. Our study suggests that patients with untreated active RA have altered lipoprotein and apolipoprotein patterns that may possibly expose them to higher risk of atherosclerosis. The inflammatory condition of RA may affect the metabolism of HDL-cholesterol and apo A1.

Original languageEnglish
Pages (from-to)1701-1704
Number of pages4
JournalJournal of Rheumatology
Volume26
Issue number8
Publication statusPublished - 1999 Aug 15

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Rheumatoid Arthritis
Apolipoprotein A-I
HDL Cholesterol
Lipids
Apolipoproteins B
Lipoprotein(a)
C-Reactive Protein
LDL Cholesterol
Cholesterol
Antirheumatic Agents
Apolipoproteins
Lipoproteins
Atherosclerosis
Adrenal Cortex Hormones
Triglycerides

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Park, Y., Lee, S. K., Lee, W. K., Suh, C. H., Lee, C. W., Lee, C. H., ... Lee, J. (1999). Lipid profiles in untreated patients with rheumatoid arthritis. Journal of Rheumatology, 26(8), 1701-1704.
Park, YongBeom ; Lee, Soo Kon ; Lee, Won Ki ; Suh, Chang Hee ; Lee, Choong Won ; Lee, Chan Hee ; Song, Chang Ho ; Lee, Jisoo. / Lipid profiles in untreated patients with rheumatoid arthritis. In: Journal of Rheumatology. 1999 ; Vol. 26, No. 8. pp. 1701-1704.
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abstract = "Objective. To investigate lipid profiles in patients with untreated active rheumatoid arthritis (RA) and to assess the relationship of the inflammatory condition of RA with lipid profiles. Methods. Forty-two patients with RA and 42 age and sex matched healthy controls were studied. Patients with RA had not been treated with corticosteroid or disease modifying antirheumatic drugs prior to the study. Total cholesterol, triglyceride, HDL- cholesterol, LDL-cholesterol, apolipoprotein A1 (apo A1), apolipoprotein B (apo B), lipoprotein(a) [Lp(a)], and C-reactive protein (CRP) were measured in both groups. Results. The levels of apo A1 and HDL-cholesterol were significantly lower in patients than in controls (128.5 vs 151.8 mg/dl, 41.2 vs 54.9 mg/dl, respectively). The level of Lp(a) was significantly higher in patients than in controls (27.1 vs 18.0 mg/dl). The ratios of apo B/apo A1, total cholesterol/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol were significantly higher in patients than in controls (0.82 vs 0.67, 4.4 vs 3.4, 2.8 vs 1.9, respectively). CRP showed a significant correlation with apo A1 (r = -0.44, p < 0.01) and HDL-cholesterol (r = -0.35, p < 0.05). Conclusion. Our study suggests that patients with untreated active RA have altered lipoprotein and apolipoprotein patterns that may possibly expose them to higher risk of atherosclerosis. The inflammatory condition of RA may affect the metabolism of HDL-cholesterol and apo A1.",
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Park, Y, Lee, SK, Lee, WK, Suh, CH, Lee, CW, Lee, CH, Song, CH & Lee, J 1999, 'Lipid profiles in untreated patients with rheumatoid arthritis', Journal of Rheumatology, vol. 26, no. 8, pp. 1701-1704.

Lipid profiles in untreated patients with rheumatoid arthritis. / Park, YongBeom; Lee, Soo Kon; Lee, Won Ki; Suh, Chang Hee; Lee, Choong Won; Lee, Chan Hee; Song, Chang Ho; Lee, Jisoo.

In: Journal of Rheumatology, Vol. 26, No. 8, 15.08.1999, p. 1701-1704.

Research output: Contribution to journalArticle

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AU - Park, YongBeom

AU - Lee, Soo Kon

AU - Lee, Won Ki

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AU - Song, Chang Ho

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N2 - Objective. To investigate lipid profiles in patients with untreated active rheumatoid arthritis (RA) and to assess the relationship of the inflammatory condition of RA with lipid profiles. Methods. Forty-two patients with RA and 42 age and sex matched healthy controls were studied. Patients with RA had not been treated with corticosteroid or disease modifying antirheumatic drugs prior to the study. Total cholesterol, triglyceride, HDL- cholesterol, LDL-cholesterol, apolipoprotein A1 (apo A1), apolipoprotein B (apo B), lipoprotein(a) [Lp(a)], and C-reactive protein (CRP) were measured in both groups. Results. The levels of apo A1 and HDL-cholesterol were significantly lower in patients than in controls (128.5 vs 151.8 mg/dl, 41.2 vs 54.9 mg/dl, respectively). The level of Lp(a) was significantly higher in patients than in controls (27.1 vs 18.0 mg/dl). The ratios of apo B/apo A1, total cholesterol/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol were significantly higher in patients than in controls (0.82 vs 0.67, 4.4 vs 3.4, 2.8 vs 1.9, respectively). CRP showed a significant correlation with apo A1 (r = -0.44, p < 0.01) and HDL-cholesterol (r = -0.35, p < 0.05). Conclusion. Our study suggests that patients with untreated active RA have altered lipoprotein and apolipoprotein patterns that may possibly expose them to higher risk of atherosclerosis. The inflammatory condition of RA may affect the metabolism of HDL-cholesterol and apo A1.

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Park Y, Lee SK, Lee WK, Suh CH, Lee CW, Lee CH et al. Lipid profiles in untreated patients with rheumatoid arthritis. Journal of Rheumatology. 1999 Aug 15;26(8):1701-1704.