Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

Dong Keon Lee, Ji Hee Kim, Wan Sung Kim, Dooil Jeoung, Hansoo Lee, Kwon Soo Ha, Moo Ho Won, Young Guen Kwon, Young Myeong Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.

Original languageEnglish
Pages (from-to)2859-2865
Number of pages7
JournalFEBS Letters
Volume589
Issue number19
DOIs
Publication statusPublished - 2015 Sep 14

Fingerprint

Macrophages
Lipopolysaccharides
Cyclooxygenase 2
Phosphorylation
Dinoprostone
mitogen and stress-activated protein kinase 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Lee, D. K., Kim, J. H., Kim, W. S., Jeoung, D., Lee, H., Ha, K. S., ... Kim, Y. M. (2015). Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages. FEBS Letters, 589(19), 2859-2865. https://doi.org/10.1016/j.febslet.2015.08.004
Lee, Dong Keon ; Kim, Ji Hee ; Kim, Wan Sung ; Jeoung, Dooil ; Lee, Hansoo ; Ha, Kwon Soo ; Won, Moo Ho ; Kwon, Young Guen ; Kim, Young Myeong. / Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages. In: FEBS Letters. 2015 ; Vol. 589, No. 19. pp. 2859-2865.
@article{4e1e0a99983c44d28e65f284aee1978a,
title = "Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages",
abstract = "REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.",
author = "Lee, {Dong Keon} and Kim, {Ji Hee} and Kim, {Wan Sung} and Dooil Jeoung and Hansoo Lee and Ha, {Kwon Soo} and Won, {Moo Ho} and Kwon, {Young Guen} and Kim, {Young Myeong}",
year = "2015",
month = "9",
day = "14",
doi = "10.1016/j.febslet.2015.08.004",
language = "English",
volume = "589",
pages = "2859--2865",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "19",

}

Lee, DK, Kim, JH, Kim, WS, Jeoung, D, Lee, H, Ha, KS, Won, MH, Kwon, YG & Kim, YM 2015, 'Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages', FEBS Letters, vol. 589, no. 19, pp. 2859-2865. https://doi.org/10.1016/j.febslet.2015.08.004

Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages. / Lee, Dong Keon; Kim, Ji Hee; Kim, Wan Sung; Jeoung, Dooil; Lee, Hansoo; Ha, Kwon Soo; Won, Moo Ho; Kwon, Young Guen; Kim, Young Myeong.

In: FEBS Letters, Vol. 589, No. 19, 14.09.2015, p. 2859-2865.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

AU - Lee, Dong Keon

AU - Kim, Ji Hee

AU - Kim, Wan Sung

AU - Jeoung, Dooil

AU - Lee, Hansoo

AU - Ha, Kwon Soo

AU - Won, Moo Ho

AU - Kwon, Young Guen

AU - Kim, Young Myeong

PY - 2015/9/14

Y1 - 2015/9/14

N2 - REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.

AB - REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.

UR - http://www.scopus.com/inward/record.url?scp=84941413430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941413430&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2015.08.004

DO - 10.1016/j.febslet.2015.08.004

M3 - Article

C2 - 26296313

AN - SCOPUS:84941413430

VL - 589

SP - 2859

EP - 2865

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 19

ER -