Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

Dong Keon Lee; Ji Hee Kim; Wan Sung Kim; Dooil Jeoung; Hansoo Lee; Kwon Soo Ha; Moo Ho Won; Young Guen Kwon; Young Myeong Kim

doi:10.1016/j.febslet.2015.08.004

Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

Dong Keon Lee, Ji Hee Kim, Wan Sung Kim, Dooil Jeoung, Hansoo Lee, Kwon Soo Ha, Moo Ho Won, Young Guen Kwon, Young Myeong Kim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE₂/PKA pathways.

Original language	English
Pages (from-to)	2859-2865
Number of pages	7
Journal	FEBS Letters
Volume	589
Issue number	19
DOIs	https://doi.org/10.1016/j.febslet.2015.08.004
Publication status	Published - 2015 Sept 14

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government ( MSIP ) ( 2013M3A9B6046563 ).

Publisher Copyright:
© 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2015.08.004

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title = "Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages",

abstract = "REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.",

author = "Lee, {Dong Keon} and Kim, {Ji Hee} and Kim, {Wan Sung} and Dooil Jeoung and Hansoo Lee and Ha, {Kwon Soo} and Won, {Moo Ho} and Kwon, {Young Guen} and Kim, {Young Myeong}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government ( MSIP ) ( 2013M3A9B6046563 ). Publisher Copyright: {\textcopyright} 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

year = "2015",

month = sep,

day = "14",

doi = "10.1016/j.febslet.2015.08.004",

language = "English",

volume = "589",

pages = "2859--2865",

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T1 - Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

AU - Lee, Dong Keon

AU - Kim, Ji Hee

AU - Kim, Wan Sung

AU - Jeoung, Dooil

AU - Lee, Hansoo

AU - Ha, Kwon Soo

AU - Won, Moo Ho

AU - Kwon, Young Guen

AU - Kim, Young Myeong

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government ( MSIP ) ( 2013M3A9B6046563 ). Publisher Copyright: © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2015/9/14

Y1 - 2015/9/14

N2 - REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.

AB - REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-κB-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PKA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PKA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE2/PKA pathways.

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ER -

Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages

Abstract

Bibliographical note

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