Liquid filled multilayered capsules for oral delivery

Yoojin Kim, Joowon Kim, Yunha Kim, Jae Hyung Jang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Nature is the precious source of inspiration for the design of new versatile materials. Diverse structures in nature have concentric multilayers surrounding liquid core. The representative examples, such as hen’s eggs and mermaid purses which indicate protective egg case of oviparous sharks, indirectly verified liquid filled capsules with rigid membrane as the upmost strategy to preserve their tribe in the evolutionary aspect. Here, we developed multilayered polymer capsules with liquid core to create the ultimate boundary protecting encapsulated cells, which can flexibly respond to the external stimuli. The coacervation induced multilayered membrane can exhibit remarkable pH-responsive properties, forming tight structure against acidic pH and generating rapid degradation in basic pH, apt to be applied as oral delivery tools. These liquid core capsules were tailored as protective delivery vehicles for viral vectors and suspending cells, especially adeno-associated virus (AAV) and natural killer cells, to be used as the non-invasive treatment for intractable diseases.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages529
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Liquid filled multilayered capsules for oral delivery'. Together they form a unique fingerprint.

Cite this