Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children

Hyun Joo Shin, Haesung Yoon, Myung Joon Kim, Seok Joo Han, Hong Koh, Seung Kim, Mi Jung Lee

Research output: Contribution to journalArticle

Abstract

AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

Original languageEnglish
Pages (from-to)3013-3020
Number of pages8
JournalWorld Journal of Gastroenterology
Volume24
Issue number27
DOIs
Publication statusPublished - 2018 Jul 21

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Liver
Fatty Liver
Elasticity Imaging Techniques
Fats
Protons
Blood Flow Velocity
Research Ethics Committees
Blood Volume
Fibrosis
Multivariate Analysis
Retrospective Studies
Perfusion

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Shin, Hyun Joo ; Yoon, Haesung ; Kim, Myung Joon ; Han, Seok Joo ; Koh, Hong ; Kim, Seung ; Lee, Mi Jung. / Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children. In: World Journal of Gastroenterology. 2018 ; Vol. 24, No. 27. pp. 3013-3020.
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abstract = "AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.",
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Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children. / Shin, Hyun Joo; Yoon, Haesung; Kim, Myung Joon; Han, Seok Joo; Koh, Hong; Kim, Seung; Lee, Mi Jung.

In: World Journal of Gastroenterology, Vol. 24, No. 27, 21.07.2018, p. 3013-3020.

Research output: Contribution to journalArticle

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T1 - Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children

AU - Shin, Hyun Joo

AU - Yoon, Haesung

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AU - Koh, Hong

AU - Kim, Seung

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N2 - AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

AB - AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

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