Abstract
AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.
| Original language | English |
|---|---|
| Pages (from-to) | 3013-3020 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 24 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - 2018 Jul 21 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children. / Shin, Hyun Joo; Yoon, Haesung; Kim, Myung Joon; Han, Seok Joo; Koh, Hong; Kim, Seung; Lee, Mi Jung.
In: World Journal of Gastroenterology, Vol. 24, No. 27, 21.07.2018, p. 3013-3020.Research output: Contribution to journal › Article
TY - JOUR
T1 - Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fbrosis in children
AU - Shin, Hyun Joo
AU - Yoon, Haesung
AU - Kim, Myung Joon
AU - Han, Seok Joo
AU - Koh, Hong
AU - Kim, Seung
AU - Lee, Mi Jung
PY - 2018/7/21
Y1 - 2018/7/21
N2 - AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.
AB - AIM To evaluate the correlation between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters and the degree of hepatic steatosis and fbrosis in children. METHODS This retrospective study was approved by the institutional review board. The children (≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver (FAT), and fbrotic liver (FIB) groups. The slow diffusion coefficient (D), fast diffusion coefficient (D∗), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured. MR proton density fat fraction (PDFF), MR elastography (MRE), and IVIM values were compared. RESULTS A total of 123 children (median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D∗ values were lower in the FIB group compared with those of the normal (P = 0.015) and FAT (P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group (P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value (β = 3.194, P < 0.001), and MRE value was negatively correlated with D∗ value (β = -7.031, P = 0.032). The D and ADC values were not infuenced by PDFF or MRE value. CONCLUSION In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffiness and endovascular blood flow velocity, while diffusion-related parameters were not affected.
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U2 - 10.3748/wjg.v24.i27.3013
DO - 10.3748/wjg.v24.i27.3013
M3 - Article
VL - 24
SP - 3013
EP - 3020
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 27
ER -