Liver stiffness measurement using FibroScan ® is influenced by serum total bilirubin in acute hepatitis

Seung Up Kim, Kwang Hyub Han, Jun Yong Park, Sang Hoon Ahn, Moon Jae Chung, Chae Yoon Chon, Eun Hee Choi, Do Young Kim

Research output: Contribution to journalArticle

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Abstract

Background: Liver stiffness measurement (LSM) using FibroScan ® is accepted as a highly reproducible and accurate technique for assessment of liver fibrosis. However, several studies have indicated that the LSM value can be significantly influenced by major changes in aminotransferases in patients with chronic viral hepatitis and LSM is unreliable for diagnosing underlying liver cirrhosis in patients with acute liver damage. We aimed to determine biochemical factors influencing the LSM value in patients with acute hepatitis. Methods: From July to December 2007, a total of 60 patients with acute hepatitis of varying aetiologies were recruited prospectively. LSM and biochemical tests were performed at diagnosis and recovery from acute hepatitis. Results: The mean age of the patients (38 men and 22 women) was 40.7 ± 15.4 years. The aetiology of acute hepatitis included hepatitis A virus in 31 patients, drug induced in 19 and hepatitis B virus in 10. The mean LSM value was 19.6 kPa at diagnosis and 15.9 kPa at recovery. Correlation analysis showed that the LSM value at diagnosis was significantly associated with platelet count (P = 0.023), alanine aminotransferase (P = 0.045), albumin (P < 0.001), total bilirubin (P = 0.004) and prothrombin time (P = 0.005). However, additional correlation analysis between the changes in LSM value and biochemical factors from diagnosis to recovery showed that the change in total bilirubin was found to be the only factor associated with the change in the LSM value (P < 0.001). Conclusions: Our data suggest that the LSM value might be influenced by serum total bilirubin in patients with acute hepatitis without pre-existing underlying chronic liver disease.

Original languageEnglish
Pages (from-to)810-815
Number of pages6
JournalLiver International
Volume29
Issue number6
DOIs
Publication statusPublished - 2009 Jun 19

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Bilirubin
Hepatitis
Liver
Serum
Liver Cirrhosis
Hepatitis A virus
Prothrombin Time
Chronic Hepatitis
Transaminases
Alanine Transaminase
Platelet Count
Hepatitis B virus
Liver Diseases
Albumins
Chronic Disease

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

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title = "Liver stiffness measurement using FibroScan {\circledR} is influenced by serum total bilirubin in acute hepatitis",
abstract = "Background: Liver stiffness measurement (LSM) using FibroScan {\circledR} is accepted as a highly reproducible and accurate technique for assessment of liver fibrosis. However, several studies have indicated that the LSM value can be significantly influenced by major changes in aminotransferases in patients with chronic viral hepatitis and LSM is unreliable for diagnosing underlying liver cirrhosis in patients with acute liver damage. We aimed to determine biochemical factors influencing the LSM value in patients with acute hepatitis. Methods: From July to December 2007, a total of 60 patients with acute hepatitis of varying aetiologies were recruited prospectively. LSM and biochemical tests were performed at diagnosis and recovery from acute hepatitis. Results: The mean age of the patients (38 men and 22 women) was 40.7 ± 15.4 years. The aetiology of acute hepatitis included hepatitis A virus in 31 patients, drug induced in 19 and hepatitis B virus in 10. The mean LSM value was 19.6 kPa at diagnosis and 15.9 kPa at recovery. Correlation analysis showed that the LSM value at diagnosis was significantly associated with platelet count (P = 0.023), alanine aminotransferase (P = 0.045), albumin (P < 0.001), total bilirubin (P = 0.004) and prothrombin time (P = 0.005). However, additional correlation analysis between the changes in LSM value and biochemical factors from diagnosis to recovery showed that the change in total bilirubin was found to be the only factor associated with the change in the LSM value (P < 0.001). Conclusions: Our data suggest that the LSM value might be influenced by serum total bilirubin in patients with acute hepatitis without pre-existing underlying chronic liver disease.",
author = "Kim, {Seung Up} and Han, {Kwang Hyub} and Park, {Jun Yong} and Ahn, {Sang Hoon} and Chung, {Moon Jae} and Chon, {Chae Yoon} and Choi, {Eun Hee} and Kim, {Do Young}",
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Liver stiffness measurement using FibroScan ® is influenced by serum total bilirubin in acute hepatitis. / Kim, Seung Up; Han, Kwang Hyub; Park, Jun Yong; Ahn, Sang Hoon; Chung, Moon Jae; Chon, Chae Yoon; Choi, Eun Hee; Kim, Do Young.

In: Liver International, Vol. 29, No. 6, 19.06.2009, p. 810-815.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Liver stiffness measurement using FibroScan ® is influenced by serum total bilirubin in acute hepatitis

AU - Kim, Seung Up

AU - Han, Kwang Hyub

AU - Park, Jun Yong

AU - Ahn, Sang Hoon

AU - Chung, Moon Jae

AU - Chon, Chae Yoon

AU - Choi, Eun Hee

AU - Kim, Do Young

PY - 2009/6/19

Y1 - 2009/6/19

N2 - Background: Liver stiffness measurement (LSM) using FibroScan ® is accepted as a highly reproducible and accurate technique for assessment of liver fibrosis. However, several studies have indicated that the LSM value can be significantly influenced by major changes in aminotransferases in patients with chronic viral hepatitis and LSM is unreliable for diagnosing underlying liver cirrhosis in patients with acute liver damage. We aimed to determine biochemical factors influencing the LSM value in patients with acute hepatitis. Methods: From July to December 2007, a total of 60 patients with acute hepatitis of varying aetiologies were recruited prospectively. LSM and biochemical tests were performed at diagnosis and recovery from acute hepatitis. Results: The mean age of the patients (38 men and 22 women) was 40.7 ± 15.4 years. The aetiology of acute hepatitis included hepatitis A virus in 31 patients, drug induced in 19 and hepatitis B virus in 10. The mean LSM value was 19.6 kPa at diagnosis and 15.9 kPa at recovery. Correlation analysis showed that the LSM value at diagnosis was significantly associated with platelet count (P = 0.023), alanine aminotransferase (P = 0.045), albumin (P < 0.001), total bilirubin (P = 0.004) and prothrombin time (P = 0.005). However, additional correlation analysis between the changes in LSM value and biochemical factors from diagnosis to recovery showed that the change in total bilirubin was found to be the only factor associated with the change in the LSM value (P < 0.001). Conclusions: Our data suggest that the LSM value might be influenced by serum total bilirubin in patients with acute hepatitis without pre-existing underlying chronic liver disease.

AB - Background: Liver stiffness measurement (LSM) using FibroScan ® is accepted as a highly reproducible and accurate technique for assessment of liver fibrosis. However, several studies have indicated that the LSM value can be significantly influenced by major changes in aminotransferases in patients with chronic viral hepatitis and LSM is unreliable for diagnosing underlying liver cirrhosis in patients with acute liver damage. We aimed to determine biochemical factors influencing the LSM value in patients with acute hepatitis. Methods: From July to December 2007, a total of 60 patients with acute hepatitis of varying aetiologies were recruited prospectively. LSM and biochemical tests were performed at diagnosis and recovery from acute hepatitis. Results: The mean age of the patients (38 men and 22 women) was 40.7 ± 15.4 years. The aetiology of acute hepatitis included hepatitis A virus in 31 patients, drug induced in 19 and hepatitis B virus in 10. The mean LSM value was 19.6 kPa at diagnosis and 15.9 kPa at recovery. Correlation analysis showed that the LSM value at diagnosis was significantly associated with platelet count (P = 0.023), alanine aminotransferase (P = 0.045), albumin (P < 0.001), total bilirubin (P = 0.004) and prothrombin time (P = 0.005). However, additional correlation analysis between the changes in LSM value and biochemical factors from diagnosis to recovery showed that the change in total bilirubin was found to be the only factor associated with the change in the LSM value (P < 0.001). Conclusions: Our data suggest that the LSM value might be influenced by serum total bilirubin in patients with acute hepatitis without pre-existing underlying chronic liver disease.

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