Liver tissue engineering: Recent advances in the development of a bio-artificial liver

Jung Seung Lee, Seung-Woo Cho

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Orthotopic liver transplantation is the most common treatment for patients with end-stage liver failure. However, liver transplantation is greatly limited by a donor shortage. Liver tissue engineering may offer a promising strategy to solve this problem by providing transplantable, bioartificial livers. Diverse types of cells, biomaterials, and growth factor delivery systems have been tested for efficient regeneration of liver tissues that possess hepatic functions comparable to native livers. This article reviews recent advances in liver tissue engineering and describes cell sources, biomaterial scaffolds, and growth factor delivery systems that are currently being used to improve the regenerative potential of tissue-engineered livers.

Original languageEnglish
Pages (from-to)427-438
Number of pages12
JournalBiotechnology and Bioprocess Engineering
Volume17
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Artificial Liver
Tissue Engineering
Tissue engineering
Liver
Biocompatible Materials
Liver Transplantation
Intercellular Signaling Peptides and Proteins
Liver Regeneration
Liver Failure
Biomaterials
Tissue
Tissue Donors
Scaffolds (biology)

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Biomedical Engineering

Cite this

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Liver tissue engineering : Recent advances in the development of a bio-artificial liver. / Lee, Jung Seung; Cho, Seung-Woo.

In: Biotechnology and Bioprocess Engineering, Vol. 17, No. 3, 01.06.2012, p. 427-438.

Research output: Contribution to journalReview article

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