Liver tissue engineering: Recent advances in the development of a bio-artificial liver

Jung Seung Lee, Seung Woo Cho

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Orthotopic liver transplantation is the most common treatment for patients with end-stage liver failure. However, liver transplantation is greatly limited by a donor shortage. Liver tissue engineering may offer a promising strategy to solve this problem by providing transplantable, bioartificial livers. Diverse types of cells, biomaterials, and growth factor delivery systems have been tested for efficient regeneration of liver tissues that possess hepatic functions comparable to native livers. This article reviews recent advances in liver tissue engineering and describes cell sources, biomaterial scaffolds, and growth factor delivery systems that are currently being used to improve the regenerative potential of tissue-engineered livers.

Original languageEnglish
Pages (from-to)427-438
Number of pages12
JournalBiotechnology and Bioprocess Engineering
Volume17
Issue number3
DOIs
Publication statusPublished - 2012 Jun

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Biomedical Engineering

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