Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: A national multicenter analysis

Chang Sik Yu; Hae Ran Yun; Eung Jin Shin; Kang Yong Lee; Nam Kyu Kim; Seok Byung Lim; Seong Taek Oh; Sung Bum Kang; Won Joon Choi; Woo Yong Lee

doi:10.1016/j.amjsurg.2013.01.042

Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: A national multicenter analysis

Chang Sik Yu, Hae Ran Yun, Eung Jin Shin, Kang Yong Lee, Nam Kyu Kim, Seok Byung Lim, Seong Taek Oh, Sung Bum Kang, Won Joon Choi, Woo Yong Lee

Department of Surgery

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.

Original language	English
Pages (from-to)	482-487
Number of pages	6
Journal	American Journal of Surgery
Volume	206
Issue number	4
DOIs	https://doi.org/10.1016/j.amjsurg.2013.01.042
Publication status	Published - 2013 Oct

Bibliographical note

Funding Information:
Supported in part by the Korean Society of Coloproctology .

All Science Journal Classification (ASJC) codes

Surgery

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10.1016/j.amjsurg.2013.01.042

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title = "Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: A national multicenter analysis",

abstract = "Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.",

author = "Yu, {Chang Sik} and Yun, {Hae Ran} and Shin, {Eung Jin} and Lee, {Kang Yong} and Kim, {Nam Kyu} and Lim, {Seok Byung} and Oh, {Seong Taek} and Kang, {Sung Bum} and Choi, {Won Joon} and Lee, {Woo Yong}",

note = "Funding Information: Supported in part by the Korean Society of Coloproctology . ",

year = "2013",

month = oct,

doi = "10.1016/j.amjsurg.2013.01.042",

language = "English",

volume = "206",

pages = "482--487",

journal = "American Journal of Surgery",

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T1 - Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer

T2 - A national multicenter analysis

AU - Yu, Chang Sik

AU - Yun, Hae Ran

AU - Shin, Eung Jin

AU - Lee, Kang Yong

AU - Kim, Nam Kyu

AU - Lim, Seok Byung

AU - Oh, Seong Taek

AU - Kang, Sung Bum

AU - Choi, Won Joon

AU - Lee, Woo Yong

N1 - Funding Information: Supported in part by the Korean Society of Coloproctology .

PY - 2013/10

Y1 - 2013/10

N2 - Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.

AB - Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.

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Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: A national multicenter analysis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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