Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer

A national multicenter analysis

Chang Sik Yu, Hae Ran Yun, Eung Jin Shin, Kang Yong Lee, Namkyu Kim, Seok Byung Lim, Seong Taek Oh, Sung Bum Kang, Won Joon Choi, Woo Yong Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.

Original languageEnglish
Pages (from-to)482-487
Number of pages6
JournalAmerican Journal of Surgery
Volume206
Issue number4
DOIs
Publication statusPublished - 2013 Oct 1

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Neoadjuvant Therapy
Rectal Neoplasms
Recurrence
Neoplasm Metastasis
Korea
Disease-Free Survival
Survival Rate
Lymph Nodes
Morbidity

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Yu, Chang Sik ; Yun, Hae Ran ; Shin, Eung Jin ; Lee, Kang Yong ; Kim, Namkyu ; Lim, Seok Byung ; Oh, Seong Taek ; Kang, Sung Bum ; Choi, Won Joon ; Lee, Woo Yong. / Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer : A national multicenter analysis. In: American Journal of Surgery. 2013 ; Vol. 206, No. 4. pp. 482-487.
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Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer : A national multicenter analysis. / Yu, Chang Sik; Yun, Hae Ran; Shin, Eung Jin; Lee, Kang Yong; Kim, Namkyu; Lim, Seok Byung; Oh, Seong Taek; Kang, Sung Bum; Choi, Won Joon; Lee, Woo Yong.

In: American Journal of Surgery, Vol. 206, No. 4, 01.10.2013, p. 482-487.

Research output: Contribution to journalArticle

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AU - Kim, Namkyu

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AU - Oh, Seong Taek

AU - Kang, Sung Bum

AU - Choi, Won Joon

AU - Lee, Woo Yong

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N2 - Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P =.040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.

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