Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning

Hansung Jung, Philippa H. Francis-West, Randall B. Widelitz, Ting Xin Jiang, Sheree Ting-Berreth, Cheryll Tickle, Lewis Wolpert, Cheng Ming Chuong

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

The formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented.

Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalDevelopmental Biology
Volume196
Issue number1
DOIs
Publication statusPublished - 1998 Apr 1

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Feathers
Computer Simulation
Mental Competency
Theoretical Models
Epithelium

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Jung, Hansung ; Francis-West, Philippa H. ; Widelitz, Randall B. ; Jiang, Ting Xin ; Ting-Berreth, Sheree ; Tickle, Cheryll ; Wolpert, Lewis ; Chuong, Cheng Ming. / Local inhibitory action of BMPs and their relationships with activators in feather formation : Implications for periodic patterning. In: Developmental Biology. 1998 ; Vol. 196, No. 1. pp. 11-23.
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abstract = "The formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented.",
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Jung, H, Francis-West, PH, Widelitz, RB, Jiang, TX, Ting-Berreth, S, Tickle, C, Wolpert, L & Chuong, CM 1998, 'Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning', Developmental Biology, vol. 196, no. 1, pp. 11-23. https://doi.org/10.1006/dbio.1998.8850

Local inhibitory action of BMPs and their relationships with activators in feather formation : Implications for periodic patterning. / Jung, Hansung; Francis-West, Philippa H.; Widelitz, Randall B.; Jiang, Ting Xin; Ting-Berreth, Sheree; Tickle, Cheryll; Wolpert, Lewis; Chuong, Cheng Ming.

In: Developmental Biology, Vol. 196, No. 1, 01.04.1998, p. 11-23.

Research output: Contribution to journalArticle

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AU - Wolpert, Lewis

AU - Chuong, Cheng Ming

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