Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

Young Jin Jung, hoonchul kang, Keom Ok Choi, Joon Soo Lee, Dong Seok Kim, Jae Hyun Cho, Shin Hye Kim, Chang Hwan Im, HeungDong Kim

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introduction: Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. Methods: We analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. Results: The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. Discussions: Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalSeizure
Volume20
Issue number6
DOIs
Publication statusPublished - 2011 Jul 1

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Stroke
Generalized Epilepsy
Partial Epilepsy
Neuroimaging
Electroencephalography
Epilepsy
Electrodes
Electrocorticography
Lennox Gastaut Syndrome
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Jung, Young Jin ; kang, hoonchul ; Choi, Keom Ok ; Lee, Joon Soo ; Kim, Dong Seok ; Cho, Jae Hyun ; Kim, Shin Hye ; Im, Chang Hwan ; Kim, HeungDong. / Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography. In: Seizure. 2011 ; Vol. 20, No. 6. pp. 449-457.
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Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography. / Jung, Young Jin; kang, hoonchul; Choi, Keom Ok; Lee, Joon Soo; Kim, Dong Seok; Cho, Jae Hyun; Kim, Shin Hye; Im, Chang Hwan; Kim, HeungDong.

In: Seizure, Vol. 20, No. 6, 01.07.2011, p. 449-457.

Research output: Contribution to journalArticle

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