Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method

Jae Hyun Cho, Young Jin Jung, hoonchul kang, HeungDong Kim, Chang Hwan Im

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones, however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. We analyzed ictal iEEG data acquired from three patients with LGS. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages5020-5023
Number of pages4
DOIs
Publication statusPublished - 2011 Dec 26
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: 2011 Aug 302011 Sep 3

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period11/8/3011/9/3

Fingerprint

Electroencephalography
Transfer functions
Stroke
Neuroimaging
Surgery
Partial Epilepsy
Electrodes
Epilepsy
Lennox Gastaut Syndrome
Electrocorticography

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Cho, J. H., Jung, Y. J., kang, H., Kim, H., & Im, C. H. (2011). Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 5020-5023). [6091244] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6091244
Cho, Jae Hyun ; Jung, Young Jin ; kang, hoonchul ; Kim, HeungDong ; Im, Chang Hwan. / Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 5020-5023 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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Cho, JH, Jung, YJ, kang, H, Kim, H & Im, CH 2011, Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6091244, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 5020-5023, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 11/8/30. https://doi.org/10.1109/IEMBS.2011.6091244

Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. / Cho, Jae Hyun; Jung, Young Jin; kang, hoonchul; Kim, HeungDong; Im, Chang Hwan.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 5020-5023 6091244 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Cho JH, Jung YJ, kang H, Kim H, Im CH. Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 5020-5023. 6091244. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6091244