Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23

Ji Yeon Lee, Hye Sun Park, Seunghee Han, Jiyu Kelly Lim, Namki Hong, Sung Il Park, Yumie Rhee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of 68 Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.

Original languageEnglish
Pages (from-to)981-987
Number of pages7
JournalYonsei medical journal
Volume58
Issue number5
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Neoplasms
Hypophosphatemia
fibroblast growth factor 23
Oncogenic osteomalacia
Serum
Positron Emission Tomography Computed Tomography
Edotreotide

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Ji Yeon ; Park, Hye Sun ; Han, Seunghee ; Lim, Jiyu Kelly ; Hong, Namki ; Park, Sung Il ; Rhee, Yumie. / Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23. In: Yonsei medical journal. 2017 ; Vol. 58, No. 5. pp. 981-987.
@article{d349d9d1ab7045bfbad7dfd790bf49a6,
title = "Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23",
abstract = "Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of 68 Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.",
author = "Lee, {Ji Yeon} and Park, {Hye Sun} and Seunghee Han and Lim, {Jiyu Kelly} and Namki Hong and Park, {Sung Il} and Yumie Rhee",
year = "2017",
month = "1",
day = "1",
doi = "10.3349/ymj.2017.58.5.981",
language = "English",
volume = "58",
pages = "981--987",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "5",

}

Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23. / Lee, Ji Yeon; Park, Hye Sun; Han, Seunghee; Lim, Jiyu Kelly; Hong, Namki; Park, Sung Il; Rhee, Yumie.

In: Yonsei medical journal, Vol. 58, No. 5, 01.01.2017, p. 981-987.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23

AU - Lee, Ji Yeon

AU - Park, Hye Sun

AU - Han, Seunghee

AU - Lim, Jiyu Kelly

AU - Hong, Namki

AU - Park, Sung Il

AU - Rhee, Yumie

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of 68 Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.

AB - Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of 68 Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.

UR - http://www.scopus.com/inward/record.url?scp=85027254217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027254217&partnerID=8YFLogxK

U2 - 10.3349/ymj.2017.58.5.981

DO - 10.3349/ymj.2017.58.5.981

M3 - Article

C2 - 28792142

AN - SCOPUS:85027254217

VL - 58

SP - 981

EP - 987

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 5

ER -