Localization of primary cilia in mouse retina

Yong Kyu Kim, Jin Hyoung Kim, Young Suk Yu, Hyuk Wan Ko, Jeong Hun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The primary cilia are considered as "cellular antennae" that sense and interchange information with the extracellular environment. Nearly all mammalian cells have a single primary cilium. In the retina, the outer segment of the photoreceptor is known to be a specialized form of primary cilium, but studies on cilia in other layers of the retina are scarce. In this study, we investigated the expression of primary cilia in the whole thickness of the mouse retina using immunofluorescence with three different ciliary markers: Arl13b, acetylated α-tubulin and adenylyl cyclase III. Our results show positive reactions in the photoreceptor layer, outer plexiform layer and ganglion cell layer, which might suggest the possible presence of primary cilia in these areas, but we could not directly prove the strand-like shape of cilia in those areas. In the outer plexiform layer, all three markers showed intense staining along the neuronal synapses, which suggests that the neuronal processes themselves might share the features of cilia.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalActa Histochemica
Volume115
Issue number8
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Cilia
Retina
Tubulin
Ganglia
Synapses
Fluorescent Antibody Technique
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Histology
  • Cell Biology

Cite this

Kim, Yong Kyu ; Kim, Jin Hyoung ; Yu, Young Suk ; Ko, Hyuk Wan ; Kim, Jeong Hun. / Localization of primary cilia in mouse retina. In: Acta Histochemica. 2013 ; Vol. 115, No. 8. pp. 789-794.
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Kim, YK, Kim, JH, Yu, YS, Ko, HW & Kim, JH 2013, 'Localization of primary cilia in mouse retina', Acta Histochemica, vol. 115, no. 8, pp. 789-794. https://doi.org/10.1016/j.acthis.2013.03.005

Localization of primary cilia in mouse retina. / Kim, Yong Kyu; Kim, Jin Hyoung; Yu, Young Suk; Ko, Hyuk Wan; Kim, Jeong Hun.

In: Acta Histochemica, Vol. 115, No. 8, 01.10.2013, p. 789-794.

Research output: Contribution to journalArticle

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