Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model

Kang Il Song; Seul Lee; Sunghee E. Park; Dosik Hwang; Hyungmin Kim; Inchan Youn

doi:10.1109/EMBC.2017.8037026

Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model

Kang Il Song, Seul Lee, Sunghee E. Park, Dosik Hwang, Hyungmin Kim, Inchan Youn

Department of Electrical and Electronic Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.

Original language	English
Title of host publication	2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Smarter Technology for a Healthier World, EMBC 2017 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1122-1125
Number of pages	4
ISBN (Electronic)	9781509028092
DOIs	https://doi.org/10.1109/EMBC.2017.8037026
Publication status	Published - 2017 Sep 13
Event	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of Duration: 2017 Jul 11 → 2017 Jul 15

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Other

Other	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Country	Korea, Republic of
City	Jeju Island
Period	17/7/11 → 17/7/15

Bibliographical note

Funding Information:
This research was supported in part by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of the Republic of Korea (Grant Number: HI14C3477) and in part by the Next-Generation Medical Device Development Program for Newly-Created Market of the National Research Foundation (NRF), funded by the Korean government, MSIP (No: 2015M3D5A1066100).

Publisher Copyright:
© 2017 IEEE.

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Song, K. I., Lee, S., Park, S. E., Hwang, D., Kim, H., & Youn, I. (2017). Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 1122-1125). [8037026] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037026

Song, Kang Il ; Lee, Seul ; Park, Sunghee E. ; Hwang, Dosik ; Kim, Hyungmin ; Youn, Inchan. / Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1122-1125 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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abstract = "A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.",

author = "Song, {Kang Il} and Seul Lee and Park, {Sunghee E.} and Dosik Hwang and Hyungmin Kim and Inchan Youn",

note = "Funding Information: This research was supported in part by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of the Republic of Korea (Grant Number: HI14C3477) and in part by the Next-Generation Medical Device Development Program for Newly-Created Market of the National Research Foundation (NRF), funded by the Korean government, MSIP (No: 2015M3D5A1066100). Publisher Copyright: {\textcopyright} 2017 IEEE.; 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 ; Conference date: 11-07-2017 Through 15-07-2017",

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Song, KI, Lee, S, Park, SE, Hwang, D, Kim, H & Youn, I 2017, Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8037026, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1122-1125, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 17/7/11. https://doi.org/10.1109/EMBC.2017.8037026

Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. / Song, Kang Il; Lee, Seul; Park, Sunghee E.; Hwang, Dosik; Kim, Hyungmin; Youn, Inchan.

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1122-1125 8037026 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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N1 - Funding Information: This research was supported in part by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of the Republic of Korea (Grant Number: HI14C3477) and in part by the Next-Generation Medical Device Development Program for Newly-Created Market of the National Research Foundation (NRF), funded by the Korean government, MSIP (No: 2015M3D5A1066100). Publisher Copyright: © 2017 IEEE.

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N2 - A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.

AB - A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.

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Song KI, Lee S, Park SE, Hwang D, Kim H, Youn I. Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1122-1125. 8037026. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2017.8037026

Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model

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