TY - GEN
T1 - Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model
AU - Song, Kang Il
AU - Lee, Seul
AU - Park, Sunghee E.
AU - Hwang, Dosik
AU - Kim, Hyungmin
AU - Youn, Inchan
PY - 2017/9/13
Y1 - 2017/9/13
N2 - A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.
AB - A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.
UR - http://www.scopus.com/inward/record.url?scp=85032196341&partnerID=8YFLogxK
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U2 - 10.1109/EMBC.2017.8037026
DO - 10.1109/EMBC.2017.8037026
M3 - Conference contribution
C2 - 29060072
AN - SCOPUS:85032196341
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1122
EP - 1125
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -