Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model

Kang Il Song, Seul Lee, Sunghee E. Park, Dosik Hwang, Hyungmin Kim, Inchan Youn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A collimator design was investigated to localize ultrasound stimulation using a flat ultrasound transducer for ultrasound-induced neuromodulation in a mouse model. In brain stimulation, the specific location of stimulation must be specified, as the region responsible for motor or sensory function is clustered in a narrow brain area. To localize ultrasound stimulation, three types of collimator design were simulated to determine the optimal collimator design. The performance of the simulated optimal collimator was compared to that of an unmounted collimator in a transducer in both in vivo and in vitro experiments. Throughout the experiments, the localized ultrasound waveform was shaped using the optimized collimator, which elicited neural spike activity in the targeted motor cortex. The optimized collimator shows potential for controlling a localized ultrasound waveform for ultrasound-induced neuromodulation in a small animal model.

Original languageEnglish
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1122-1125
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 2017 Sep 13
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 2017 Jul 112017 Jul 15

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period17/7/1117/7/15

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Song, K. I., Lee, S., Park, S. E., Hwang, D., Kim, H., & Youn, I. (2017). Localization of ultrasound waveform for low intensity ultrasound-induced neuromodulation in a mouse model. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 1122-1125). [8037026] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037026