Locally applied slow-release of minocycline microspheres in the treatment of peri-implant mucositis: An experimental in vivo study

Sung Wook Yoon, Myong Ji Kim, Kyeong Won Paeng, Kyeong Ae Yu, Chong Kil Lee, Young Woo Song, Jae Kook Cha, Mariano Sanz, Ui Won Jung

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes.

Original languageEnglish
Article number668
Pages (from-to)1-13
Number of pages13
JournalPharmaceutics
Volume12
Issue number7
DOIs
Publication statusPublished - 2020 Jul

Bibliographical note

Funding Information:
This study was funded by Dongkook Pharmaceuticals Company, Seoul, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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