Long-term ambient air pollution exposures and brain imaging markers in korean adults: The environmental pollution-induced neurological effects (epinef) study

Jaelim Cho, Young Noh, Sun Young Kim, Jungwoo Sohn, Juhwan Noh, Woojin Kim, Seong Kyung Cho, Hwasun Seo, Gayoung Seo, Seung Koo Lee, Seongho Seo, Sang Baek Koh, Sung Soo Oh, Hee Jin Kim, Sang Won Seo, Dae Seock Shin, Nakyoung Kim, Ho Hyun Kim, Jung Il Lee, Changsoo Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Only a limited number of neuroimaging studies have explored the effects of ambient air pollution in adults. The prior studies have investigated only cortical volume, and they have reported mixed findings, particularly for gray matter. Furthermore, the association between nitrogen dioxide (NO2) and neuroimaging markers has been little studied in adults. OBJECTIVES: We investigated the association between long-term exposure to air pollutants (NO2, particulate matter (PM) with aerodynamic diameters of ≤10 lm (PM10) and ≤2:5 lm (PM2.5), and neuroimaging markers. METHODS: The study included 427 men and 530 women dwelling in four cities in the Republic of Korea. Long-term concentrations of PM10, NO2, and PM2.5 at residential addresses were estimated. Neuroimaging markers (cortical thickness and subcortical volume) were obtained from brain magnetic resonance images. A generalized linear model was used, adjusting for potential confounders. RESULTS: A 10-lg=m3 increase in PM10 was associated with reduced thicknesses in the frontal [–0:02 mm (95% CI: –0:03, –0:01)] and temporal lobes [–0:06 mm (95% CI: –0:07, –0:04)]. A 10-lg=m3 increase in PM2.5 was associated with a thinner temporal cortex [–0:18 mm (95% CI: –0:27, –0:08)]. A 10-ppb increase in NO2 was associated with reduced thicknesses in the global [–0:01 mm (95% CI: –0:01, 0.00)], frontal [–0:02 mm (95% CI: –0:03, –0:01)], parietal [–0:02 mm (95% CI: –0:03, –0:01)], temporal [–0:04 mm (95% CI: –0:05, –0:03)], and insular lobes [–0:01 mm (95% CI: –0:02, 0.00)]. The air pollutants were also associated with increased thicknesses in the occipital and cingulate lobes. Subcortical structures associated with the air pollutants included the thalamus, caudate, pallidum, hippocampus, amygdala, and nucleus accumbens. DISCUSSION: The findings suggest that long-term exposure to high ambient air pollution may lead to cortical thinning and reduced subcortical volume in adults. https://doi.org/10.1289/EHP7133.

Original languageEnglish
Article number117006
Pages (from-to)1-11
Number of pages11
JournalEnvironmental Health Perspectives
Volume128
Issue number11
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Ministry of Environment under the Environmental Health Action Program (2014001360002) and by grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI18C1629 and HI14C1135).

Publisher Copyright:
© 2020, Public Health Services, US Dept of Health and Human Services. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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