Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance

Sang Hoon Ahn, Young Nyun Park, Jun Yong Park, Hye Young Chang, Jung Min Lee, Ji Eun Shin, Kwang Hyub Han, Chanil Park, Young Myoung Moon, Chae Yoon Chon

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

During the natural course of hepatitis B virus (HBV) infection, the long-term clinical and histological outcomes following spontaneous hepatitis B surface antigen (HBsAg) seroclearance remain unclear. Between 1984 and 2003, 49 (9.5%) out of 432 inactive HBsAg carriers had no detectable level of circulating HBsAg. Fifteen of 49 patients had undergone paired peritoneoscopic liver biopsies. During a mean follow-up period of 19.6 months after HBsAg seroclearance, 5 of 49 (10.2%) patients were noted to have HCC. Liver cirrhosis (P=0.040), a history of perinatal infection (P=0.005) and long-standing duration (at least 30 years) of HBsAg positivity (P=0.002) were associated with a significantly higher risk of developing HCC. Despite HBsAg seroclearance, HBV DNA was detected in the liver tissues from all 15 patients who underwent paired liver biopsies. Necroinflammation was significantly ameliorated (P<0.0001). On the other hand, amelioration of the fibrosis score did not reach a statistically significant level (P=0.072). Interestingly, aggravation of liver fibrosis was evident in 2 patients (13.3%) including one who had rapidly progressed to overt cirrhosis. In patients with spontaneous HBsAg seroclearance, necroinflammation was markedly improved and liver fibrosis was unchanged or regressed despite occult HBV infection. However, HCC developed in a minority of cases.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalJournal of Hepatology
Volume42
Issue number2
DOIs
Publication statusPublished - 2005 Feb 1

Fingerprint

Hepatitis B Surface Antigens
Hepatitis B virus
Liver Cirrhosis
Virus Diseases
Liver
Fibrosis
Biopsy
DNA
Infection

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Ahn, Sang Hoon ; Park, Young Nyun ; Park, Jun Yong ; Chang, Hye Young ; Lee, Jung Min ; Shin, Ji Eun ; Han, Kwang Hyub ; Park, Chanil ; Moon, Young Myoung ; Chon, Chae Yoon. / Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. In: Journal of Hepatology. 2005 ; Vol. 42, No. 2. pp. 188-194.
@article{903dc91f80d8478da002dbb85c153648,
title = "Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance",
abstract = "During the natural course of hepatitis B virus (HBV) infection, the long-term clinical and histological outcomes following spontaneous hepatitis B surface antigen (HBsAg) seroclearance remain unclear. Between 1984 and 2003, 49 (9.5{\%}) out of 432 inactive HBsAg carriers had no detectable level of circulating HBsAg. Fifteen of 49 patients had undergone paired peritoneoscopic liver biopsies. During a mean follow-up period of 19.6 months after HBsAg seroclearance, 5 of 49 (10.2{\%}) patients were noted to have HCC. Liver cirrhosis (P=0.040), a history of perinatal infection (P=0.005) and long-standing duration (at least 30 years) of HBsAg positivity (P=0.002) were associated with a significantly higher risk of developing HCC. Despite HBsAg seroclearance, HBV DNA was detected in the liver tissues from all 15 patients who underwent paired liver biopsies. Necroinflammation was significantly ameliorated (P<0.0001). On the other hand, amelioration of the fibrosis score did not reach a statistically significant level (P=0.072). Interestingly, aggravation of liver fibrosis was evident in 2 patients (13.3{\%}) including one who had rapidly progressed to overt cirrhosis. In patients with spontaneous HBsAg seroclearance, necroinflammation was markedly improved and liver fibrosis was unchanged or regressed despite occult HBV infection. However, HCC developed in a minority of cases.",
author = "Ahn, {Sang Hoon} and Park, {Young Nyun} and Park, {Jun Yong} and Chang, {Hye Young} and Lee, {Jung Min} and Shin, {Ji Eun} and Han, {Kwang Hyub} and Chanil Park and Moon, {Young Myoung} and Chon, {Chae Yoon}",
year = "2005",
month = "2",
day = "1",
doi = "10.1016/j.jhep.2004.10.026",
language = "English",
volume = "42",
pages = "188--194",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "2",

}

Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. / Ahn, Sang Hoon; Park, Young Nyun; Park, Jun Yong; Chang, Hye Young; Lee, Jung Min; Shin, Ji Eun; Han, Kwang Hyub; Park, Chanil; Moon, Young Myoung; Chon, Chae Yoon.

In: Journal of Hepatology, Vol. 42, No. 2, 01.02.2005, p. 188-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance

AU - Ahn, Sang Hoon

AU - Park, Young Nyun

AU - Park, Jun Yong

AU - Chang, Hye Young

AU - Lee, Jung Min

AU - Shin, Ji Eun

AU - Han, Kwang Hyub

AU - Park, Chanil

AU - Moon, Young Myoung

AU - Chon, Chae Yoon

PY - 2005/2/1

Y1 - 2005/2/1

N2 - During the natural course of hepatitis B virus (HBV) infection, the long-term clinical and histological outcomes following spontaneous hepatitis B surface antigen (HBsAg) seroclearance remain unclear. Between 1984 and 2003, 49 (9.5%) out of 432 inactive HBsAg carriers had no detectable level of circulating HBsAg. Fifteen of 49 patients had undergone paired peritoneoscopic liver biopsies. During a mean follow-up period of 19.6 months after HBsAg seroclearance, 5 of 49 (10.2%) patients were noted to have HCC. Liver cirrhosis (P=0.040), a history of perinatal infection (P=0.005) and long-standing duration (at least 30 years) of HBsAg positivity (P=0.002) were associated with a significantly higher risk of developing HCC. Despite HBsAg seroclearance, HBV DNA was detected in the liver tissues from all 15 patients who underwent paired liver biopsies. Necroinflammation was significantly ameliorated (P<0.0001). On the other hand, amelioration of the fibrosis score did not reach a statistically significant level (P=0.072). Interestingly, aggravation of liver fibrosis was evident in 2 patients (13.3%) including one who had rapidly progressed to overt cirrhosis. In patients with spontaneous HBsAg seroclearance, necroinflammation was markedly improved and liver fibrosis was unchanged or regressed despite occult HBV infection. However, HCC developed in a minority of cases.

AB - During the natural course of hepatitis B virus (HBV) infection, the long-term clinical and histological outcomes following spontaneous hepatitis B surface antigen (HBsAg) seroclearance remain unclear. Between 1984 and 2003, 49 (9.5%) out of 432 inactive HBsAg carriers had no detectable level of circulating HBsAg. Fifteen of 49 patients had undergone paired peritoneoscopic liver biopsies. During a mean follow-up period of 19.6 months after HBsAg seroclearance, 5 of 49 (10.2%) patients were noted to have HCC. Liver cirrhosis (P=0.040), a history of perinatal infection (P=0.005) and long-standing duration (at least 30 years) of HBsAg positivity (P=0.002) were associated with a significantly higher risk of developing HCC. Despite HBsAg seroclearance, HBV DNA was detected in the liver tissues from all 15 patients who underwent paired liver biopsies. Necroinflammation was significantly ameliorated (P<0.0001). On the other hand, amelioration of the fibrosis score did not reach a statistically significant level (P=0.072). Interestingly, aggravation of liver fibrosis was evident in 2 patients (13.3%) including one who had rapidly progressed to overt cirrhosis. In patients with spontaneous HBsAg seroclearance, necroinflammation was markedly improved and liver fibrosis was unchanged or regressed despite occult HBV infection. However, HCC developed in a minority of cases.

UR - http://www.scopus.com/inward/record.url?scp=19944434258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944434258&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2004.10.026

DO - 10.1016/j.jhep.2004.10.026

M3 - Article

C2 - 15664243

AN - SCOPUS:19944434258

VL - 42

SP - 188

EP - 194

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 2

ER -