Long-term clinical course of post-infectious irritable bowel syndrome after shigellosis: A 10-year follow-up study

Young Hoon Youn, Hyeon Chang Kim, Hyun Chul Lim, Jae Jun Park, Jie Hyun Kim, Hyojin Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. Methods: A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex- and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. Results: The Shigella -infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49- 95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella -infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella -infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. Conclusions: Patients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalJournal of Neurogastroenterology and Motility
Volume22
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

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Bacillary Dysentery
Irritable Bowel Syndrome
antineoplaston A10
Shigella
Shigella sonnei
Odds Ratio
Disease Outbreaks
Diarrhea
Cohort Studies
Prospective Studies
Food

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Gastroenterology

Cite this

@article{50089216919745e68a05e2363444b7d5,
title = "Long-term clinical course of post-infectious irritable bowel syndrome after shigellosis: A 10-year follow-up study",
abstract = "Background/Aims: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. Methods: A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex- and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. Results: The Shigella -infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95{\%} CI, 1.49- 95.58) and 3-year (3.93; 95{\%} CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95{\%} CI, 0.64-5.54) and 8-year (1.87; 95{\%} CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella -infected cohort and their controls (23.3{\%} versus 19.7{\%}, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella -infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. Conclusions: Patients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.",
author = "Youn, {Young Hoon} and Kim, {Hyeon Chang} and Lim, {Hyun Chul} and Park, {Jae Jun} and Kim, {Jie Hyun} and Hyojin Park",
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Long-term clinical course of post-infectious irritable bowel syndrome after shigellosis : A 10-year follow-up study. / Youn, Young Hoon; Kim, Hyeon Chang; Lim, Hyun Chul; Park, Jae Jun; Kim, Jie Hyun; Park, Hyojin.

In: Journal of Neurogastroenterology and Motility, Vol. 22, No. 3, 01.01.2016, p. 490-496.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term clinical course of post-infectious irritable bowel syndrome after shigellosis

T2 - A 10-year follow-up study

AU - Youn, Young Hoon

AU - Kim, Hyeon Chang

AU - Lim, Hyun Chul

AU - Park, Jae Jun

AU - Kim, Jie Hyun

AU - Park, Hyojin

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N2 - Background/Aims: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. Methods: A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex- and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. Results: The Shigella -infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49- 95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella -infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella -infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. Conclusions: Patients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.

AB - Background/Aims: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. Methods: A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex- and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. Results: The Shigella -infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49- 95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella -infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella -infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. Conclusions: Patients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.

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