Long-term clinical outcomes and risk factors for the occurrence of post-operative complications after cardiovascular surgery in patients with Behçet's disease

You Jung Ha, Sang Youn Jung, Kwang Hoon Lee, Se Jin Jung, Sang Won Lee, Min Chan Park, Soo Kon Lee, Won Heum Shim, Byung Chul Chang, Yong Beom Park

Research output: Contribution to journalArticle

9 Citations (Scopus)


Objective: Cardiovascular surgery in patients with Behçet's disease (BD) frequently leads to post-operative complications such as anastomotic leakage, occlusion or pseudoaneurysm. We evaluated the clinical outcomes and related risk factors of post-operative complications in BD patients undergoing cardiovascular surgeries, as well as the long-term efficiency of post-operative immunosuppressive treatment. Methods: Forty-one patients with BD who had undergone cardiovascular surgery between 1990 and 2009 were studied. We evaluated the patients' clinical data, post-operative complications, and survival rate. Risk factors related to the occurrence of post-operative complications were identified by univariate analysis using the Kaplan-Meier method with the log-rank test and multivariate analysis using the Cox proportional hazards regression model. Results: Fifty-nine operations were performed in 41 patients. During the mean follow-up period of 65.3±48.1 months, complications such as paravalvular leakage, dehiscence, fistula, graft occlusion, or pseudoaneurysm occurred in 29 operations (49.2%). The cumulative occurrence rate of postoperative complication was 10.2% at three months, 32.8% at 12 months, and 43.8% at 24 months. Upon univariate analysis, young age, high C-reactive protein levels, lack of post-operative immunosuppression, and short disease duration were identified as significant factors responsible for the occurrence of post-operative complications. In multivariate analysis, post-operative immunosuppression was found to independently lower the risk of complications. The 5-year survival rate was significantly higher in patients with post-operative immunosuppression than in those without (84.5% vs. 45.0%, p=0.011). Conclusion: The present study suggests that post-operative immunosuppressive therapy after cardiovascular surgeries in BD patients is important for reducing the development of serious post-operative complications.

Original languageEnglish
Pages (from-to)S18-S26
JournalClinical and experimental rheumatology
Issue numberSUPPL.72
Publication statusPublished - 2012 Dec 1


All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this