Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer

A prospective multicenter cohort study

Sang Gyun Kim, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Da Hyun Lyu, Seung Hee Park, Il Ju Choi, Wan Sik Lee, Seun Ja Park, Jae Jun Kim, Ji Hyun Kim, Chul Hyun Lim, Joo Young Cho, Gwang Ha Kim, Yongchan Lee, Hwoon Yong Jung, Jun Haeng Lee, Hoon Jai Chun, Sang Yong Seol

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalGut and liver
Volume12
Issue number4
DOIs
Publication statusPublished - 2018 Jul 1

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Multicenter Studies
Stomach Neoplasms
Cohort Studies
Korea
Disease-Free Survival
Survival Rate
Endoscopic Mucosal Resection
Therapeutics
Pathology
Neoplasm Metastasis
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Sang Gyun ; Park, Chan Mi ; Lee, Na Rae ; Kim, Jiyoung ; Lyu, Da Hyun ; Park, Seung Hee ; Choi, Il Ju ; Lee, Wan Sik ; Park, Seun Ja ; Kim, Jae Jun ; Kim, Ji Hyun ; Lim, Chul Hyun ; Cho, Joo Young ; Kim, Gwang Ha ; Lee, Yongchan ; Jung, Hwoon Yong ; Lee, Jun Haeng ; Chun, Hoon Jai ; Seol, Sang Yong. / Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer : A prospective multicenter cohort study. In: Gut and liver. 2018 ; Vol. 12, No. 4. pp. 402-410.
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title = "Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer: A prospective multicenter cohort study",
abstract = "Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3{\%} of the cases, and curative resection was achieved in 86.1{\%}. During the 5-year follow-up, the overall survival rate was 96.6{\%}, and the disease specific free survival rate was 90.6{\%}. Local recurrence developed in 0.9{\%}, and metachronous tumor development occurred in 7.8{\%}; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5{\%} during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.",
author = "Kim, {Sang Gyun} and Park, {Chan Mi} and Lee, {Na Rae} and Jiyoung Kim and Lyu, {Da Hyun} and Park, {Seung Hee} and Choi, {Il Ju} and Lee, {Wan Sik} and Park, {Seun Ja} and Kim, {Jae Jun} and Kim, {Ji Hyun} and Lim, {Chul Hyun} and Cho, {Joo Young} and Kim, {Gwang Ha} and Yongchan Lee and Jung, {Hwoon Yong} and Lee, {Jun Haeng} and Chun, {Hoon Jai} and Seol, {Sang Yong}",
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Kim, SG, Park, CM, Lee, NR, Kim, J, Lyu, DH, Park, SH, Choi, IJ, Lee, WS, Park, SJ, Kim, JJ, Kim, JH, Lim, CH, Cho, JY, Kim, GH, Lee, Y, Jung, HY, Lee, JH, Chun, HJ & Seol, SY 2018, 'Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer: A prospective multicenter cohort study', Gut and liver, vol. 12, no. 4, pp. 402-410. https://doi.org/10.5009/gnl17414

Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer : A prospective multicenter cohort study. / Kim, Sang Gyun; Park, Chan Mi; Lee, Na Rae; Kim, Jiyoung; Lyu, Da Hyun; Park, Seung Hee; Choi, Il Ju; Lee, Wan Sik; Park, Seun Ja; Kim, Jae Jun; Kim, Ji Hyun; Lim, Chul Hyun; Cho, Joo Young; Kim, Gwang Ha; Lee, Yongchan; Jung, Hwoon Yong; Lee, Jun Haeng; Chun, Hoon Jai; Seol, Sang Yong.

In: Gut and liver, Vol. 12, No. 4, 01.07.2018, p. 402-410.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-Term clinical outcomes of endoscopic submucosal dissection in patients with early gastric cancer

T2 - A prospective multicenter cohort study

AU - Kim, Sang Gyun

AU - Park, Chan Mi

AU - Lee, Na Rae

AU - Kim, Jiyoung

AU - Lyu, Da Hyun

AU - Park, Seung Hee

AU - Choi, Il Ju

AU - Lee, Wan Sik

AU - Park, Seun Ja

AU - Kim, Jae Jun

AU - Kim, Ji Hyun

AU - Lim, Chul Hyun

AU - Cho, Joo Young

AU - Kim, Gwang Ha

AU - Lee, Yongchan

AU - Jung, Hwoon Yong

AU - Lee, Jun Haeng

AU - Chun, Hoon Jai

AU - Seol, Sang Yong

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.

AB - Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.

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