Long-term comparison of platinum chromium everolimus-eluting stent vs. Cobalt chromium zotarolimus-eluting stent: 3-year outcomes from the HOST–ASSURE randomized clinical trial

HOST–ASSURE Investigators

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: There are limited data on the long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) vs. cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES). Methods and Results: A total of 3,755 patients undergoing percutaneous coronary intervention (PCI) were randomized 2:1 to PtCr-EES or CoCr-ZES, and 96.0% of patients completed the 3-year clinical follow-up. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR). At 3 years, TLF occurred in 5.3% and in 5.4% of the PtCr-EES and CoCr-ZES groups, respectively (hazard ratio 0.978; 95% confidence interval 0.730–1.310, P=0.919). There were no significant differences in the individual components of TLF. Routine angiographic follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that had follow-up angiography, the clinically-driven TLR rate of CoCr-ZES was significantly higher than PtCr-EES group during the angiography follow-up period (P=0.009). Overall definite and probable stent thrombosis rates were very low in both groups (0.5% vs. 0.6%, P=0.677). Conclusions: PtCr-EES and CoCr-ZES had similar and excellent long-term outcomes in both efficacy and safety after PCI in an all-comer population.

Original languageEnglish
Pages (from-to)1489-1497
Number of pages9
JournalCirculation Journal
Volume83
Issue number7
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This study was supported by an unrestricted grant from Boston Scientific Korea. The funding source had no role in the study design, data collection, monitoring, analysis, interpretation or writing of the manuscript.

Publisher Copyright:
© 2019, Japanese Circulation Society. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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