Long-term effects of repetitive transcranial magnetic stimulation in unilateral tinnitus

Hyun J. Kim, Deog Y. Kim, Hyo I. Kim, Hee S. Oh, Nam S. Sim, InSeok Moon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives/Hypothesis We investigated the long-term effects of repetitive transcranial magnetic stimulation (rTMS) delivered to the temporoparietal junction and compared contralateral and ipsilateral application in patients with unilateral tinnitus. Study Design Prospective study. Methods A total of 61 patients with asymmetric hearing loss and nonpulsatile chronic tinnitus localized to the poorer ear who were refractory to medical treatment were enrolled. Patients were randomly assigned to one of two treatment groups: 1-Hz stimulation applied to the temporoparietal junction either ipsilaterally (n = 30) or contralaterally (n = 31) to the symptomatic ear. Changes in the Tinnitus Handicap Inventory (THI) scores and self-rating visual analog scores (VAS) for loudness, awareness, and annoyance were analyzed before and after treatment for 6 months. Improved patients were defined as those with decreases in their THI scores by >10 points and 20%. Results There were no major complications or worsening of hearing. When analyzing the THI scores and VAS pre-rTMS and 6 months after rTMS, significant decreases were observed in patients overall (P < .001). For the comparison of long-term outcomes between the ipsilateral and contralateral stimulation groups, there were no differences in the degree of decrease in THI scores or VAS (P > .05). In addition, there was no significant difference in the rate of patients who improved between the ipsilateral (14 of 30) and contralateral (16 of 31) stimulation groups (P = .800). The ipsilateral group showed a more rapid improvement than the contralateral group. Conclusions Daily application of 1-Hz rTMS to the temporoparietal area is safe and has long-term beneficial effects. The laterality of stimulation is not the decisive factor. Level of Evidence 1b

Original languageEnglish
Pages (from-to)2155-2160
Number of pages6
JournalLaryngoscope
Volume124
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Tinnitus
Transcranial Magnetic Stimulation
Equipment and Supplies
Ear
Hearing Loss
Hearing
Therapeutics
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kim, Hyun J. ; Kim, Deog Y. ; Kim, Hyo I. ; Oh, Hee S. ; Sim, Nam S. ; Moon, InSeok. / Long-term effects of repetitive transcranial magnetic stimulation in unilateral tinnitus. In: Laryngoscope. 2014 ; Vol. 124, No. 9. pp. 2155-2160.
@article{a7a2e9d1b1ae4485b7f129f86090c670,
title = "Long-term effects of repetitive transcranial magnetic stimulation in unilateral tinnitus",
abstract = "Objectives/Hypothesis We investigated the long-term effects of repetitive transcranial magnetic stimulation (rTMS) delivered to the temporoparietal junction and compared contralateral and ipsilateral application in patients with unilateral tinnitus. Study Design Prospective study. Methods A total of 61 patients with asymmetric hearing loss and nonpulsatile chronic tinnitus localized to the poorer ear who were refractory to medical treatment were enrolled. Patients were randomly assigned to one of two treatment groups: 1-Hz stimulation applied to the temporoparietal junction either ipsilaterally (n = 30) or contralaterally (n = 31) to the symptomatic ear. Changes in the Tinnitus Handicap Inventory (THI) scores and self-rating visual analog scores (VAS) for loudness, awareness, and annoyance were analyzed before and after treatment for 6 months. Improved patients were defined as those with decreases in their THI scores by >10 points and 20{\%}. Results There were no major complications or worsening of hearing. When analyzing the THI scores and VAS pre-rTMS and 6 months after rTMS, significant decreases were observed in patients overall (P < .001). For the comparison of long-term outcomes between the ipsilateral and contralateral stimulation groups, there were no differences in the degree of decrease in THI scores or VAS (P > .05). In addition, there was no significant difference in the rate of patients who improved between the ipsilateral (14 of 30) and contralateral (16 of 31) stimulation groups (P = .800). The ipsilateral group showed a more rapid improvement than the contralateral group. Conclusions Daily application of 1-Hz rTMS to the temporoparietal area is safe and has long-term beneficial effects. The laterality of stimulation is not the decisive factor. Level of Evidence 1b",
author = "Kim, {Hyun J.} and Kim, {Deog Y.} and Kim, {Hyo I.} and Oh, {Hee S.} and Sim, {Nam S.} and InSeok Moon",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/lary.24722",
language = "English",
volume = "124",
pages = "2155--2160",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

Long-term effects of repetitive transcranial magnetic stimulation in unilateral tinnitus. / Kim, Hyun J.; Kim, Deog Y.; Kim, Hyo I.; Oh, Hee S.; Sim, Nam S.; Moon, InSeok.

In: Laryngoscope, Vol. 124, No. 9, 01.01.2014, p. 2155-2160.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term effects of repetitive transcranial magnetic stimulation in unilateral tinnitus

AU - Kim, Hyun J.

AU - Kim, Deog Y.

AU - Kim, Hyo I.

AU - Oh, Hee S.

AU - Sim, Nam S.

AU - Moon, InSeok

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objectives/Hypothesis We investigated the long-term effects of repetitive transcranial magnetic stimulation (rTMS) delivered to the temporoparietal junction and compared contralateral and ipsilateral application in patients with unilateral tinnitus. Study Design Prospective study. Methods A total of 61 patients with asymmetric hearing loss and nonpulsatile chronic tinnitus localized to the poorer ear who were refractory to medical treatment were enrolled. Patients were randomly assigned to one of two treatment groups: 1-Hz stimulation applied to the temporoparietal junction either ipsilaterally (n = 30) or contralaterally (n = 31) to the symptomatic ear. Changes in the Tinnitus Handicap Inventory (THI) scores and self-rating visual analog scores (VAS) for loudness, awareness, and annoyance were analyzed before and after treatment for 6 months. Improved patients were defined as those with decreases in their THI scores by >10 points and 20%. Results There were no major complications or worsening of hearing. When analyzing the THI scores and VAS pre-rTMS and 6 months after rTMS, significant decreases were observed in patients overall (P < .001). For the comparison of long-term outcomes between the ipsilateral and contralateral stimulation groups, there were no differences in the degree of decrease in THI scores or VAS (P > .05). In addition, there was no significant difference in the rate of patients who improved between the ipsilateral (14 of 30) and contralateral (16 of 31) stimulation groups (P = .800). The ipsilateral group showed a more rapid improvement than the contralateral group. Conclusions Daily application of 1-Hz rTMS to the temporoparietal area is safe and has long-term beneficial effects. The laterality of stimulation is not the decisive factor. Level of Evidence 1b

AB - Objectives/Hypothesis We investigated the long-term effects of repetitive transcranial magnetic stimulation (rTMS) delivered to the temporoparietal junction and compared contralateral and ipsilateral application in patients with unilateral tinnitus. Study Design Prospective study. Methods A total of 61 patients with asymmetric hearing loss and nonpulsatile chronic tinnitus localized to the poorer ear who were refractory to medical treatment were enrolled. Patients were randomly assigned to one of two treatment groups: 1-Hz stimulation applied to the temporoparietal junction either ipsilaterally (n = 30) or contralaterally (n = 31) to the symptomatic ear. Changes in the Tinnitus Handicap Inventory (THI) scores and self-rating visual analog scores (VAS) for loudness, awareness, and annoyance were analyzed before and after treatment for 6 months. Improved patients were defined as those with decreases in their THI scores by >10 points and 20%. Results There were no major complications or worsening of hearing. When analyzing the THI scores and VAS pre-rTMS and 6 months after rTMS, significant decreases were observed in patients overall (P < .001). For the comparison of long-term outcomes between the ipsilateral and contralateral stimulation groups, there were no differences in the degree of decrease in THI scores or VAS (P > .05). In addition, there was no significant difference in the rate of patients who improved between the ipsilateral (14 of 30) and contralateral (16 of 31) stimulation groups (P = .800). The ipsilateral group showed a more rapid improvement than the contralateral group. Conclusions Daily application of 1-Hz rTMS to the temporoparietal area is safe and has long-term beneficial effects. The laterality of stimulation is not the decisive factor. Level of Evidence 1b

UR - http://www.scopus.com/inward/record.url?scp=84906938948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906938948&partnerID=8YFLogxK

U2 - 10.1002/lary.24722

DO - 10.1002/lary.24722

M3 - Article

C2 - 24737198

AN - SCOPUS:84906938948

VL - 124

SP - 2155

EP - 2160

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 9

ER -