Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice

Gyeong Min Do, Eun Young Kwon, Hye Jin Kim, Seon Min Jeon, Tae Youl Ha, Taesun Park, Myung Sook Choi

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Atherosclerosis is a chronic inflammatory disease of the arteries resulting from interactions between lipids, monocytes, and arterial wall cells. The effects of resveratrol supplements (RV, 0.02% and 0.06% each, w/w) with regard to the modulation of lipid profiles, cholesterol synthesis, and anti-atherogenesis were examined in apo E-deficient (apo E -/- ) mice fed a normal diet. The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo E -/- mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo E -/- mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo E -/- mice that were fed a normal diet.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume374
Issue number1
DOIs
Publication statusPublished - 2008 Sep 12

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Apolipoproteins E
Cholesterol
Nutrition
Plasmas
Control Groups
Atherosclerosis
Diet
Aryldialkylphosphatase
Hydroxymethylglutaryl CoA Reductases
Lipids
Clofibrate
Vascular Cell Adhesion Molecule-1
resveratrol
LDL Cholesterol
Cell Wall
Monocytes
Chronic Disease
Adhesion
Arteries
Fats

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Do, Gyeong Min ; Kwon, Eun Young ; Kim, Hye Jin ; Jeon, Seon Min ; Ha, Tae Youl ; Park, Taesun ; Choi, Myung Sook. / Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 374, No. 1. pp. 55-59.
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Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. / Do, Gyeong Min; Kwon, Eun Young; Kim, Hye Jin; Jeon, Seon Min; Ha, Tae Youl; Park, Taesun; Choi, Myung Sook.

In: Biochemical and Biophysical Research Communications, Vol. 374, No. 1, 12.09.2008, p. 55-59.

Research output: Contribution to journalArticle

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T1 - Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice

AU - Do, Gyeong Min

AU - Kwon, Eun Young

AU - Kim, Hye Jin

AU - Jeon, Seon Min

AU - Ha, Tae Youl

AU - Park, Taesun

AU - Choi, Myung Sook

PY - 2008/9/12

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N2 - Atherosclerosis is a chronic inflammatory disease of the arteries resulting from interactions between lipids, monocytes, and arterial wall cells. The effects of resveratrol supplements (RV, 0.02% and 0.06% each, w/w) with regard to the modulation of lipid profiles, cholesterol synthesis, and anti-atherogenesis were examined in apo E-deficient (apo E -/- ) mice fed a normal diet. The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo E -/- mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo E -/- mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo E -/- mice that were fed a normal diet.

AB - Atherosclerosis is a chronic inflammatory disease of the arteries resulting from interactions between lipids, monocytes, and arterial wall cells. The effects of resveratrol supplements (RV, 0.02% and 0.06% each, w/w) with regard to the modulation of lipid profiles, cholesterol synthesis, and anti-atherogenesis were examined in apo E-deficient (apo E -/- ) mice fed a normal diet. The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo E -/- mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo E -/- mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo E -/- mice that were fed a normal diet.

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