Abstract
The term “long-term epilepsy-associated tumor (LEAT)” encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.
| Original language | English |
|---|---|
| Pages (from-to) | 172-178 |
| Number of pages | 7 |
| Journal | Brain Tumor Pathology |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2017 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Clinical Neurology
- Cancer Research
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Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy : report of a rare case having intranuclear filaments. / Cha, Yoon Jin; Kim, Dong Seok; Lee, Seung Koo; kang, hoonchul; Kim, SeHoon.
In: Brain Tumor Pathology, Vol. 34, No. 4, 01.10.2017, p. 172-178.Research output: Contribution to journal › Article
TY - JOUR
T1 - Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy
T2 - report of a rare case having intranuclear filaments
AU - Cha, Yoon Jin
AU - Kim, Dong Seok
AU - Lee, Seung Koo
AU - kang, hoonchul
AU - Kim, SeHoon
PY - 2017/10/1
Y1 - 2017/10/1
N2 - The term “long-term epilepsy-associated tumor (LEAT)” encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.
AB - The term “long-term epilepsy-associated tumor (LEAT)” encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.
UR - http://www.scopus.com/inward/record.url?scp=85027095908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027095908&partnerID=8YFLogxK
U2 - 10.1007/s10014-017-0294-8
DO - 10.1007/s10014-017-0294-8
M3 - Article
VL - 34
SP - 172
EP - 178
JO - Brain Tumor Pathology
JF - Brain Tumor Pathology
SN - 1433-7398
IS - 4
ER -