Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy

report of a rare case having intranuclear filaments

Yoon Jin Cha, Dong Seok Kim, Seung Koo Lee, hoonchul kang, SeHoon Kim

Research output: Contribution to journalArticle

Abstract

The term “long-term epilepsy-associated tumor (LEAT)” encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalBrain Tumor Pathology
Volume34
Issue number4
DOIs
Publication statusPublished - 2017 Oct 1

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Amygdala
Epilepsy
Neoplasms
Intranuclear Inclusion Bodies
Nestin
Cell Aggregation
Synaptophysin
Intermediate Filaments
Oligodendroglia
Brain Neoplasms
Needles
Seizures
Transcription Factors
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

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title = "Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments",
abstract = "The term “long-term epilepsy-associated tumor (LEAT)” encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.",
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Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy : report of a rare case having intranuclear filaments. / Cha, Yoon Jin; Kim, Dong Seok; Lee, Seung Koo; kang, hoonchul; Kim, SeHoon.

In: Brain Tumor Pathology, Vol. 34, No. 4, 01.10.2017, p. 172-178.

Research output: Contribution to journalArticle

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