Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus after Ischemic Stroke

Ji Hyeon Ahn, Jung Hoon Choi, Joon Ha Park, In Hye Kim, Jeong Hwi Cho, Jae Chul Lee, Hyun Mo Koo, Gak Hwangbo, Ki Yeon Yoo, Choong Hyun Lee, In Koo Hwang, Jun Hwi Cho, Soo Young Choi, Young Guen Kwon, Young Myeong Kim, Il Jun Kang, Moo Ho Won

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30 Citations (Scopus)

Abstract

Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term exercise begun after ischemic neuronal death as a chronic neurorestorative strategy has not yet been thoroughly examined. Objective. The purpose of this study is to investigate possible mechanisms by which exercise ameliorates ischemia-induced memory impairment in the aged gerbil hippocampus after transient cerebral ischemia. Methods. Treadmill exercise was begun 5 days after ischemia-reperfusion (I-R) and lasted for 1 or 4 weeks. The animals were sacrificed 31 days after the induction of ischemia. Changes in short-term memory, as well as the hippocampal expression of markers of cell proliferation, neuroblast differentiation, neurogenesis, myelin and microvessel repair, and growth factors were examined by immunohistochemistry and/or western blots. Results. Four weeks of exercise facilitated memory recovery despite neuronal damage in the stratum pyramidale (SP) of the hippocampal CA1 region and in the polymorphic layer (PoL) of the dentate gyrus (DG) after I-R. Long-term exercise enhanced cell proliferation and neuroblast differentiation in a time-dependent manner, and newly generated mature cells were found in the granule cell layer of the DG, but not in the SP of the CA1 region or in the PoL of the DG. In addition, long-term exercise ameliorated ischemia-induced damage of myelin and microvessels, which was correlated with increased BDNF expression in the CA1 region and the DG. Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus.

Original languageEnglish
Pages (from-to)894-905
Number of pages12
JournalNeurorehabilitation and Neural Repair
Volume30
Issue number9
DOIs
Publication statusPublished - 2016 Oct 1

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Neurology
  • Clinical Neurology

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    Ahn, J. H., Choi, J. H., Park, J. H., Kim, I. H., Cho, J. H., Lee, J. C., Koo, H. M., Hwangbo, G., Yoo, K. Y., Lee, C. H., Hwang, I. K., Cho, J. H., Choi, S. Y., Kwon, Y. G., Kim, Y. M., Kang, I. J., & Won, M. H. (2016). Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus after Ischemic Stroke. Neurorehabilitation and Neural Repair, 30(9), 894-905. https://doi.org/10.1177/1545968316638444