Long-term exercise training attenuates age-related diastolic dysfunction: Association of myocardial collagen cross-linking

Su Yeon Choi, Hyuk Jae Chang, Sang Il Choi, Kwang Il Kim, Yong Seok Cho, Tae Jin Youn, Woo Young Chung, In Ho Chae, Dong Ju Choi, Hyo Soo Kim, Cheol Ho Kim, Byung Hee Oh, Mi Hyang Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (τ) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalJournal of Korean medical science
Volume24
Issue number1
DOIs
Publication statusPublished - 2009 Feb 1

Fingerprint

Collagen
Exercise
Blood Pressure
Diastolic Heart Failure
Pressure
Advanced Glycosylation End Products
Pepsin A
Inbred F344 Rats
Solubility
Myocardium
Catheters
Magnetic Resonance Imaging
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Choi, Su Yeon ; Chang, Hyuk Jae ; Choi, Sang Il ; Kim, Kwang Il ; Cho, Yong Seok ; Youn, Tae Jin ; Chung, Woo Young ; Chae, In Ho ; Choi, Dong Ju ; Kim, Hyo Soo ; Kim, Cheol Ho ; Oh, Byung Hee ; Kim, Mi Hyang. / Long-term exercise training attenuates age-related diastolic dysfunction : Association of myocardial collagen cross-linking. In: Journal of Korean medical science. 2009 ; Vol. 24, No. 1. pp. 32-39.
@article{3b0da6070ce945049e28e34d8bbf6f3a,
title = "Long-term exercise training attenuates age-related diastolic dysfunction: Association of myocardial collagen cross-linking",
abstract = "The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (τ) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.",
author = "Choi, {Su Yeon} and Chang, {Hyuk Jae} and Choi, {Sang Il} and Kim, {Kwang Il} and Cho, {Yong Seok} and Youn, {Tae Jin} and Chung, {Woo Young} and Chae, {In Ho} and Choi, {Dong Ju} and Kim, {Hyo Soo} and Kim, {Cheol Ho} and Oh, {Byung Hee} and Kim, {Mi Hyang}",
year = "2009",
month = "2",
day = "1",
doi = "10.3346/jkms.2009.24.1.32",
language = "English",
volume = "24",
pages = "32--39",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "1",

}

Choi, SY, Chang, HJ, Choi, SI, Kim, KI, Cho, YS, Youn, TJ, Chung, WY, Chae, IH, Choi, DJ, Kim, HS, Kim, CH, Oh, BH & Kim, MH 2009, 'Long-term exercise training attenuates age-related diastolic dysfunction: Association of myocardial collagen cross-linking', Journal of Korean medical science, vol. 24, no. 1, pp. 32-39. https://doi.org/10.3346/jkms.2009.24.1.32

Long-term exercise training attenuates age-related diastolic dysfunction : Association of myocardial collagen cross-linking. / Choi, Su Yeon; Chang, Hyuk Jae; Choi, Sang Il; Kim, Kwang Il; Cho, Yong Seok; Youn, Tae Jin; Chung, Woo Young; Chae, In Ho; Choi, Dong Ju; Kim, Hyo Soo; Kim, Cheol Ho; Oh, Byung Hee; Kim, Mi Hyang.

In: Journal of Korean medical science, Vol. 24, No. 1, 01.02.2009, p. 32-39.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term exercise training attenuates age-related diastolic dysfunction

T2 - Association of myocardial collagen cross-linking

AU - Choi, Su Yeon

AU - Chang, Hyuk Jae

AU - Choi, Sang Il

AU - Kim, Kwang Il

AU - Cho, Yong Seok

AU - Youn, Tae Jin

AU - Chung, Woo Young

AU - Chae, In Ho

AU - Choi, Dong Ju

AU - Kim, Hyo Soo

AU - Kim, Cheol Ho

AU - Oh, Byung Hee

AU - Kim, Mi Hyang

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (τ) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.

AB - The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (τ) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.

UR - http://www.scopus.com/inward/record.url?scp=65649095110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649095110&partnerID=8YFLogxK

U2 - 10.3346/jkms.2009.24.1.32

DO - 10.3346/jkms.2009.24.1.32

M3 - Article

C2 - 19270810

AN - SCOPUS:65649095110

VL - 24

SP - 32

EP - 39

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 1

ER -