Long-term follow-up results of stereotactic adrenal medullary transplantation in Parkinson's disease

S. S. Chung, Y. G. Park, JinWoo Chang, J. Cho

Research output: Contribution to journalArticle

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Abstract

Stereotactic adrenal medullary transplantation into the striatum was performed in 5 patients with severe Parkinson's disease. Four patients had previously been treated with thalamotomies and all were on L-dopa therapy with significant side effects. All 5 patients had shown marked disability before the procedure. Autologous adrenal medullary tissue was sliced into 20-30 fragments and transplanted into two sites of the caudate nucleus, one at the ventricular surface and the other in the head of the nucleus. The cases were followed for 4-5 years (mean 4.5 years), except for 1 patient who died of unrelated causes 22 months after the procedure. Initial bilateral symptom improvement was observed in all cases for 9-21 months (mean 15.2 months) after transplantation without L-dopa therapy. Later, these improvements progressively deteriorated. L-dopa therapy had to be resumed for all. MRI on the long-term follow-up showed the transplanted tissue as a low sigual intensity area surrounded by high intensity spots in T1- and T2-weighted images. Compared to previous MR studies, the transplanted tissue was shrunken and presumed nonviable.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalStereotactic and functional neurosurgery
Volume62
Issue number1-4
DOIs
Publication statusPublished - 1994 Dec 1

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Parkinson Disease
Levodopa
Transplantation
Caudate Nucleus
Therapeutics
Head

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

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abstract = "Stereotactic adrenal medullary transplantation into the striatum was performed in 5 patients with severe Parkinson's disease. Four patients had previously been treated with thalamotomies and all were on L-dopa therapy with significant side effects. All 5 patients had shown marked disability before the procedure. Autologous adrenal medullary tissue was sliced into 20-30 fragments and transplanted into two sites of the caudate nucleus, one at the ventricular surface and the other in the head of the nucleus. The cases were followed for 4-5 years (mean 4.5 years), except for 1 patient who died of unrelated causes 22 months after the procedure. Initial bilateral symptom improvement was observed in all cases for 9-21 months (mean 15.2 months) after transplantation without L-dopa therapy. Later, these improvements progressively deteriorated. L-dopa therapy had to be resumed for all. MRI on the long-term follow-up showed the transplanted tissue as a low sigual intensity area surrounded by high intensity spots in T1- and T2-weighted images. Compared to previous MR studies, the transplanted tissue was shrunken and presumed nonviable.",
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Long-term follow-up results of stereotactic adrenal medullary transplantation in Parkinson's disease. / Chung, S. S.; Park, Y. G.; Chang, JinWoo; Cho, J.

In: Stereotactic and functional neurosurgery, Vol. 62, No. 1-4, 01.12.1994, p. 141-147.

Research output: Contribution to journalArticle

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