Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment

Byung Soh Min, Nam Kyu Kim, Yong Taek Ko, Kang Young Lee, Seung Hyuk Baek, Chang Hwan Cho, Seung Kook Sohn

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Abstract

Aim: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer. Materials and methods: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study. Results: Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4% in the pT1 group and 75.0% in the pT2 group (p=0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p=0.038). Conclusion: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality.

Original languageEnglish
Pages (from-to)1325-1330
Number of pages6
JournalInternational Journal of Colorectal Disease
Volume22
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

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Rectal Neoplasms
Radiotherapy
Therapeutics
Recurrence
Neoplasms
Residual Neoplasm
Korea
Ultrasonography
Adenocarcinoma
Survival Rate
Radiation
Carcinoma

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Min, Byung Soh ; Kim, Nam Kyu ; Ko, Yong Taek ; Lee, Kang Young ; Baek, Seung Hyuk ; Cho, Chang Hwan ; Sohn, Seung Kook. / Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment. In: International Journal of Colorectal Disease. 2007 ; Vol. 22, No. 11. pp. 1325-1330.
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abstract = "Aim: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer. Materials and methods: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study. Results: Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4{\%} in the pT1 group and 75.0{\%} in the pT2 group (p=0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100{\%}, compared to those who did not, 76.0{\%} (p=0.038). Conclusion: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality.",
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Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment. / Min, Byung Soh; Kim, Nam Kyu; Ko, Yong Taek; Lee, Kang Young; Baek, Seung Hyuk; Cho, Chang Hwan; Sohn, Seung Kook.

In: International Journal of Colorectal Disease, Vol. 22, No. 11, 01.11.2007, p. 1325-1330.

Research output: Contribution to journalArticle

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T1 - Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment

AU - Min, Byung Soh

AU - Kim, Nam Kyu

AU - Ko, Yong Taek

AU - Lee, Kang Young

AU - Baek, Seung Hyuk

AU - Cho, Chang Hwan

AU - Sohn, Seung Kook

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Aim: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer. Materials and methods: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study. Results: Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4% in the pT1 group and 75.0% in the pT2 group (p=0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p=0.038). Conclusion: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality.

AB - Aim: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer. Materials and methods: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study. Results: Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4% in the pT1 group and 75.0% in the pT2 group (p=0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p=0.038). Conclusion: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality.

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