Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis.

K. H. Choi, S. I. Kim, S. Y. Yoon, J. H. Kim, S. W. Kang, S. K. Ha, H. Y. Lee, D. S. Han, Y. S. Kim, K. Park, H. J. Jeong, D. K. Kim

Research output: Contribution to journalArticle

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Abstract

Focal segmental glomerulosclerosis (FSGS) is an important cause of nephrotic syndrome and end-stage renal disease. FSGS recurrence after renal transplantation has a potentially detrimental course leading to the loss of renal function. In order to establish FSGS recurrence rates and evaluate the course of the disease on living-related-donor renal transplantation in ethnic Korean adults (> or = 18 years), we reviewed our experiences of 27 kidney transplantations with FSGS over the last 15 years. Of the 27 renal allografts, 13 were found to have recurrent FSGS by graft biopsy. In comparison with background data upon patients with and without recurrence of FSGS, the donor age of patients with recurrent FSGS was significantly higher than that of those without recurrence (median, 39 years vs 26, p < 0.05). In terms of, age at transplantation, length of dialysis period, and mode of dialysis no differences were found between recurrent and nonrecurrent cases. The graft survival rate of recipients from a kidney donor of age less than 40 years was significantly higher than that of recipients from a kidney donor of age more than 40 years, at 5 and 10 years, respectively (87% vs 33%, 41% vs 0%, p < 0.05). The association between clinical variables and recurrence was assessed by multiple logistic regression analysis, and donor age was found to be a risk factor of FSGS recurrence (p<0.05). Variables such as HLA-mismatch numbers and immunosuppression were not found to be associated. In conclusion, the recurrence rate of FSGS in adult recipients with FSGS was 48% and patients that received kidney from an older donor appear to be at higher risk of developing recurrence. The use of a renal graft from a younger donor is considered advisable for adult recipients with FSGS.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalYonsei medical journal
Volume42
Issue number2
DOIs
Publication statusPublished - 2001 Apr

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Focal Segmental Glomerulosclerosis
Kidney Transplantation
Recurrence
Tissue Donors
Kidney
Dialysis
Transplants
Living Donors
Nephrotic Syndrome
Graft Survival
Immunosuppression
Chronic Kidney Failure
Allografts
Survival Rate
Transplantation
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Choi, K. H. ; Kim, S. I. ; Yoon, S. Y. ; Kim, J. H. ; Kang, S. W. ; Ha, S. K. ; Lee, H. Y. ; Han, D. S. ; Kim, Y. S. ; Park, K. ; Jeong, H. J. ; Kim, D. K. / Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis. In: Yonsei medical journal. 2001 ; Vol. 42, No. 2. pp. 209-214.
@article{0360865d6a0f47b2a438a96a7bb788f3,
title = "Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis.",
abstract = "Focal segmental glomerulosclerosis (FSGS) is an important cause of nephrotic syndrome and end-stage renal disease. FSGS recurrence after renal transplantation has a potentially detrimental course leading to the loss of renal function. In order to establish FSGS recurrence rates and evaluate the course of the disease on living-related-donor renal transplantation in ethnic Korean adults (> or = 18 years), we reviewed our experiences of 27 kidney transplantations with FSGS over the last 15 years. Of the 27 renal allografts, 13 were found to have recurrent FSGS by graft biopsy. In comparison with background data upon patients with and without recurrence of FSGS, the donor age of patients with recurrent FSGS was significantly higher than that of those without recurrence (median, 39 years vs 26, p < 0.05). In terms of, age at transplantation, length of dialysis period, and mode of dialysis no differences were found between recurrent and nonrecurrent cases. The graft survival rate of recipients from a kidney donor of age less than 40 years was significantly higher than that of recipients from a kidney donor of age more than 40 years, at 5 and 10 years, respectively (87{\%} vs 33{\%}, 41{\%} vs 0{\%}, p < 0.05). The association between clinical variables and recurrence was assessed by multiple logistic regression analysis, and donor age was found to be a risk factor of FSGS recurrence (p<0.05). Variables such as HLA-mismatch numbers and immunosuppression were not found to be associated. In conclusion, the recurrence rate of FSGS in adult recipients with FSGS was 48{\%} and patients that received kidney from an older donor appear to be at higher risk of developing recurrence. The use of a renal graft from a younger donor is considered advisable for adult recipients with FSGS.",
author = "Choi, {K. H.} and Kim, {S. I.} and Yoon, {S. Y.} and Kim, {J. H.} and Kang, {S. W.} and Ha, {S. K.} and Lee, {H. Y.} and Han, {D. S.} and Kim, {Y. S.} and K. Park and Jeong, {H. J.} and Kim, {D. K.}",
year = "2001",
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doi = "10.3349/ymj.2001.42.2.209",
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Choi, KH, Kim, SI, Yoon, SY, Kim, JH, Kang, SW, Ha, SK, Lee, HY, Han, DS, Kim, YS, Park, K, Jeong, HJ & Kim, DK 2001, 'Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis.', Yonsei medical journal, vol. 42, no. 2, pp. 209-214. https://doi.org/10.3349/ymj.2001.42.2.209

Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis. / Choi, K. H.; Kim, S. I.; Yoon, S. Y.; Kim, J. H.; Kang, S. W.; Ha, S. K.; Lee, H. Y.; Han, D. S.; Kim, Y. S.; Park, K.; Jeong, H. J.; Kim, D. K.

In: Yonsei medical journal, Vol. 42, No. 2, 04.2001, p. 209-214.

Research output: Contribution to journalArticle

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T1 - Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis.

AU - Choi, K. H.

AU - Kim, S. I.

AU - Yoon, S. Y.

AU - Kim, J. H.

AU - Kang, S. W.

AU - Ha, S. K.

AU - Lee, H. Y.

AU - Han, D. S.

AU - Kim, Y. S.

AU - Park, K.

AU - Jeong, H. J.

AU - Kim, D. K.

PY - 2001/4

Y1 - 2001/4

N2 - Focal segmental glomerulosclerosis (FSGS) is an important cause of nephrotic syndrome and end-stage renal disease. FSGS recurrence after renal transplantation has a potentially detrimental course leading to the loss of renal function. In order to establish FSGS recurrence rates and evaluate the course of the disease on living-related-donor renal transplantation in ethnic Korean adults (> or = 18 years), we reviewed our experiences of 27 kidney transplantations with FSGS over the last 15 years. Of the 27 renal allografts, 13 were found to have recurrent FSGS by graft biopsy. In comparison with background data upon patients with and without recurrence of FSGS, the donor age of patients with recurrent FSGS was significantly higher than that of those without recurrence (median, 39 years vs 26, p < 0.05). In terms of, age at transplantation, length of dialysis period, and mode of dialysis no differences were found between recurrent and nonrecurrent cases. The graft survival rate of recipients from a kidney donor of age less than 40 years was significantly higher than that of recipients from a kidney donor of age more than 40 years, at 5 and 10 years, respectively (87% vs 33%, 41% vs 0%, p < 0.05). The association between clinical variables and recurrence was assessed by multiple logistic regression analysis, and donor age was found to be a risk factor of FSGS recurrence (p<0.05). Variables such as HLA-mismatch numbers and immunosuppression were not found to be associated. In conclusion, the recurrence rate of FSGS in adult recipients with FSGS was 48% and patients that received kidney from an older donor appear to be at higher risk of developing recurrence. The use of a renal graft from a younger donor is considered advisable for adult recipients with FSGS.

AB - Focal segmental glomerulosclerosis (FSGS) is an important cause of nephrotic syndrome and end-stage renal disease. FSGS recurrence after renal transplantation has a potentially detrimental course leading to the loss of renal function. In order to establish FSGS recurrence rates and evaluate the course of the disease on living-related-donor renal transplantation in ethnic Korean adults (> or = 18 years), we reviewed our experiences of 27 kidney transplantations with FSGS over the last 15 years. Of the 27 renal allografts, 13 were found to have recurrent FSGS by graft biopsy. In comparison with background data upon patients with and without recurrence of FSGS, the donor age of patients with recurrent FSGS was significantly higher than that of those without recurrence (median, 39 years vs 26, p < 0.05). In terms of, age at transplantation, length of dialysis period, and mode of dialysis no differences were found between recurrent and nonrecurrent cases. The graft survival rate of recipients from a kidney donor of age less than 40 years was significantly higher than that of recipients from a kidney donor of age more than 40 years, at 5 and 10 years, respectively (87% vs 33%, 41% vs 0%, p < 0.05). The association between clinical variables and recurrence was assessed by multiple logistic regression analysis, and donor age was found to be a risk factor of FSGS recurrence (p<0.05). Variables such as HLA-mismatch numbers and immunosuppression were not found to be associated. In conclusion, the recurrence rate of FSGS in adult recipients with FSGS was 48% and patients that received kidney from an older donor appear to be at higher risk of developing recurrence. The use of a renal graft from a younger donor is considered advisable for adult recipients with FSGS.

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