Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome

Joon Won Kang, Soyong Eom, William Hong, Hye Eun Kwon, Soyoung Park, Ara Ko, Hoon Chul Kang, Joon Soo Lee, Young Mock Lee, Dong Seok Kim, Heung Dong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

objective: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). methods: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. results: At the time of surgery the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1-11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). conclusions: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function.

Original languageEnglish
Article numbere20180449
JournalPediatrics
Volume142
Issue number4
DOIs
Publication statusPublished - 2018 Oct

Fingerprint

Epilepsy
Seizures
Hemispherectomy
Lennox Gastaut Syndrome
Malformations of Cortical Development
Psychological Adaptation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Won Kang, Joon ; Eom, Soyong ; Hong, William ; Kwon, Hye Eun ; Park, Soyoung ; Ko, Ara ; Kang, Hoon Chul ; Lee, Joon Soo ; Lee, Young Mock ; Kim, Dong Seok ; Kim, Heung Dong. / Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome. In: Pediatrics. 2018 ; Vol. 142, No. 4.
@article{881c9920b7074926a24d5d93720b5162,
title = "Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome",
abstract = "objective: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). methods: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. results: At the time of surgery the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1-11.4 years), 45 patients (50.0{\%}) had no seizures, and 15 (16.7{\%}) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4{\%}) hemispherectomies, 23 of the 51 (45.1{\%}) multilobar resections, and 7 of the 18 (38.9{\%}) single lobar resections. On high-resolution MRIs, 20 patients (22.2{\%}) had negative findings, 8 of whom (40.0{\%}) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3{\%}). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). conclusions: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function.",
author = "{Won Kang}, Joon and Soyong Eom and William Hong and Kwon, {Hye Eun} and Soyoung Park and Ara Ko and Kang, {Hoon Chul} and Lee, {Joon Soo} and Lee, {Young Mock} and Kim, {Dong Seok} and Kim, {Heung Dong}",
year = "2018",
month = "10",
doi = "10.1542/peds.2018-0449",
language = "English",
volume = "142",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "4",

}

Won Kang, J, Eom, S, Hong, W, Kwon, HE, Park, S, Ko, A, Kang, HC, Lee, JS, Lee, YM, Kim, DS & Kim, HD 2018, 'Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome', Pediatrics, vol. 142, no. 4, e20180449. https://doi.org/10.1542/peds.2018-0449

Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome. / Won Kang, Joon; Eom, Soyong; Hong, William; Kwon, Hye Eun; Park, Soyoung; Ko, Ara; Kang, Hoon Chul; Lee, Joon Soo; Lee, Young Mock; Kim, Dong Seok; Kim, Heung Dong.

In: Pediatrics, Vol. 142, No. 4, e20180449, 10.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome

AU - Won Kang, Joon

AU - Eom, Soyong

AU - Hong, William

AU - Kwon, Hye Eun

AU - Park, Soyoung

AU - Ko, Ara

AU - Kang, Hoon Chul

AU - Lee, Joon Soo

AU - Lee, Young Mock

AU - Kim, Dong Seok

AU - Kim, Heung Dong

PY - 2018/10

Y1 - 2018/10

N2 - objective: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). methods: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. results: At the time of surgery the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1-11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). conclusions: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function.

AB - objective: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). methods: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. results: At the time of surgery the patients were between 3.0 and 23.5 years old (mean ± SD: 9.3 ± 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 ± 4.3). On postoperative follow-up for an average period of 6.1 ± 2.2 years (range: 2.1-11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). conclusions: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function.

UR - http://www.scopus.com/inward/record.url?scp=85054064388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054064388&partnerID=8YFLogxK

U2 - 10.1542/peds.2018-0449

DO - 10.1542/peds.2018-0449

M3 - Article

C2 - 30194277

AN - SCOPUS:85054064388

VL - 142

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

M1 - e20180449

ER -