Long-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors

Jae Hwang Cha, Da Hyun Jung, Jie Hyun Kim, Young Hoon Youn, Hyojin Park, Jae Jun Park, Yoo Jin Um, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim, Hyun Jung Lee

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Abstract

The present study aimed to investigate treatment strategies determining additional treatment after endoscopic resection (ER) of rectal neuroendocrine tumor (NET)s and long-term outcomes of endoscopically resected rectal NETs. We analyzed a total of 322 patients medical records of patients who underwent ER for rectal NETs. Rectal NETs initially resected as polyps and treated with conventional endoscopic mucosal resection (EMR) were observed more frequently in the non-curative group (P = 0.041 and P = 0.012, respectively). After ER, only 44 of the 142 patients (31.0%) who did not meet the criteria for curative resection received additional salvage treatment. In multivariate analysis, lesions diagnosed via biopsies (OR, 0.096; P = 0.002) or suspected as NETs initially (OR, 0.04; P = 0.001) were less likely to undergo additional treatment. Positive lymphovascular invasion (OR 61.971; P < 0.001), positive (OR 75.993; P < 0.001), or indeterminate (OR 13.203; P = 0.001) resection margins were more likely to undergo additional treatment. Although lymph node metastasis was found in 6 patients, none experienced local or metastatic tumor recurrence during the median follow-up of 40.49 months. Long-term outcomes after ER for rectal NETs were excellent. The prognosis showed favorable outcomes regardless of whether patients receive additional salvage treatments.

Original languageEnglish
Article number4911
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Neuroendocrine Tumors
Salvage Therapy
Therapeutics
Rectal Neoplasms
Polyps
Medical Records
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Biopsy
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • General

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Cha, Jae Hwang ; Jung, Da Hyun ; Kim, Jie Hyun ; Youn, Young Hoon ; Park, Hyojin ; Park, Jae Jun ; Um, Yoo Jin ; Park, Soo Jung ; Cheon, Jae Hee ; Kim, Tae Il ; Kim, Won Ho ; Lee, Hyun Jung. / Long-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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abstract = "The present study aimed to investigate treatment strategies determining additional treatment after endoscopic resection (ER) of rectal neuroendocrine tumor (NET)s and long-term outcomes of endoscopically resected rectal NETs. We analyzed a total of 322 patients medical records of patients who underwent ER for rectal NETs. Rectal NETs initially resected as polyps and treated with conventional endoscopic mucosal resection (EMR) were observed more frequently in the non-curative group (P = 0.041 and P = 0.012, respectively). After ER, only 44 of the 142 patients (31.0{\%}) who did not meet the criteria for curative resection received additional salvage treatment. In multivariate analysis, lesions diagnosed via biopsies (OR, 0.096; P = 0.002) or suspected as NETs initially (OR, 0.04; P = 0.001) were less likely to undergo additional treatment. Positive lymphovascular invasion (OR 61.971; P < 0.001), positive (OR 75.993; P < 0.001), or indeterminate (OR 13.203; P = 0.001) resection margins were more likely to undergo additional treatment. Although lymph node metastasis was found in 6 patients, none experienced local or metastatic tumor recurrence during the median follow-up of 40.49 months. Long-term outcomes after ER for rectal NETs were excellent. The prognosis showed favorable outcomes regardless of whether patients receive additional salvage treatments.",
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Long-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors. / Cha, Jae Hwang; Jung, Da Hyun; Kim, Jie Hyun; Youn, Young Hoon; Park, Hyojin; Park, Jae Jun; Um, Yoo Jin; Park, Soo Jung; Cheon, Jae Hee; Kim, Tae Il; Kim, Won Ho; Lee, Hyun Jung.

In: Scientific reports, Vol. 9, No. 1, 4911, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Cha, Jae Hwang

AU - Jung, Da Hyun

AU - Kim, Jie Hyun

AU - Youn, Young Hoon

AU - Park, Hyojin

AU - Park, Jae Jun

AU - Um, Yoo Jin

AU - Park, Soo Jung

AU - Cheon, Jae Hee

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Lee, Hyun Jung

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