Abstract
Purpose: Self-expandable metallic stents (SEMS) may be used in acute, obstructing, left-sided colorectal cancer (CRC) to avoid high-risk emergency surgery. However, the data regarding the long-term effects of SEMS as a bridge to surgery are limited and contradictory. Our aim is to analyze the long-term oncological outcomes of SEMS compared with surgery. Methods: Between January 2006 and November 2013, a total of 855 patients with stage III CRC were regularly followed at the CRC clinic of Severance Hospital, Seoul, Korea. We retrospectively evaluated their 5-year disease-free survival (DFS), 5-year overall survival (OS), and 5-year cancer-specific survival (CSS). Results: There were 94 patients in the SEMS group, 17 in the emergent-surgery group, and 744 in the elective-surgery group. In the short term, the rate of permanent stoma formation was significantly higher in the emergent-surgery group than in the SEMS group (p = 0.030), although the median hospital stay and overall complication rate were comparable. During the long-term follow-up period, oncological outcomes including 5-year DFS (70.2 vs 52.9%; p = 0.210), OS (70.2 vs 52.9%; p = 0.148), and CSS (79.8 vs 70.6%; p = 0.342) were not different between the SEMS group and the emergent-surgery group. Multivariate analysis showed emergent operation to be a significant risk factor of DFS (hazard ratio [HR], 3.117; 95% confidence interval [CI], 1.498–6.489; p = 0.002). Conclusions: Preoperative SEMS insertion does not adversely affect long-term oncological outcomes or patient survival.
| Original language | English |
|---|---|
| Pages (from-to) | 799-807 |
| Number of pages | 9 |
| Journal | International Journal of Colorectal Disease |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Long-term outcomes after stenting as a bridge to surgery in patients with obstructing left-sided colorectal cancer. / Park, Jihye; Lee, Hyun Jung; Park, Soo Jung; Hur, Hyuk; Min, Byung Soh; Cheon, Jae Hee; Kim, Tae Il; Kim, Nam Kyu; Kim, Won Ho.
In: International Journal of Colorectal Disease, Vol. 33, No. 6, 01.06.2018, p. 799-807.Research output: Contribution to journal › Article
TY - JOUR
T1 - Long-term outcomes after stenting as a bridge to surgery in patients with obstructing left-sided colorectal cancer
AU - Park, Jihye
AU - Lee, Hyun Jung
AU - Park, Soo Jung
AU - Hur, Hyuk
AU - Min, Byung Soh
AU - Cheon, Jae Hee
AU - Kim, Tae Il
AU - Kim, Nam Kyu
AU - Kim, Won Ho
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Purpose: Self-expandable metallic stents (SEMS) may be used in acute, obstructing, left-sided colorectal cancer (CRC) to avoid high-risk emergency surgery. However, the data regarding the long-term effects of SEMS as a bridge to surgery are limited and contradictory. Our aim is to analyze the long-term oncological outcomes of SEMS compared with surgery. Methods: Between January 2006 and November 2013, a total of 855 patients with stage III CRC were regularly followed at the CRC clinic of Severance Hospital, Seoul, Korea. We retrospectively evaluated their 5-year disease-free survival (DFS), 5-year overall survival (OS), and 5-year cancer-specific survival (CSS). Results: There were 94 patients in the SEMS group, 17 in the emergent-surgery group, and 744 in the elective-surgery group. In the short term, the rate of permanent stoma formation was significantly higher in the emergent-surgery group than in the SEMS group (p = 0.030), although the median hospital stay and overall complication rate were comparable. During the long-term follow-up period, oncological outcomes including 5-year DFS (70.2 vs 52.9%; p = 0.210), OS (70.2 vs 52.9%; p = 0.148), and CSS (79.8 vs 70.6%; p = 0.342) were not different between the SEMS group and the emergent-surgery group. Multivariate analysis showed emergent operation to be a significant risk factor of DFS (hazard ratio [HR], 3.117; 95% confidence interval [CI], 1.498–6.489; p = 0.002). Conclusions: Preoperative SEMS insertion does not adversely affect long-term oncological outcomes or patient survival.
AB - Purpose: Self-expandable metallic stents (SEMS) may be used in acute, obstructing, left-sided colorectal cancer (CRC) to avoid high-risk emergency surgery. However, the data regarding the long-term effects of SEMS as a bridge to surgery are limited and contradictory. Our aim is to analyze the long-term oncological outcomes of SEMS compared with surgery. Methods: Between January 2006 and November 2013, a total of 855 patients with stage III CRC were regularly followed at the CRC clinic of Severance Hospital, Seoul, Korea. We retrospectively evaluated their 5-year disease-free survival (DFS), 5-year overall survival (OS), and 5-year cancer-specific survival (CSS). Results: There were 94 patients in the SEMS group, 17 in the emergent-surgery group, and 744 in the elective-surgery group. In the short term, the rate of permanent stoma formation was significantly higher in the emergent-surgery group than in the SEMS group (p = 0.030), although the median hospital stay and overall complication rate were comparable. During the long-term follow-up period, oncological outcomes including 5-year DFS (70.2 vs 52.9%; p = 0.210), OS (70.2 vs 52.9%; p = 0.148), and CSS (79.8 vs 70.6%; p = 0.342) were not different between the SEMS group and the emergent-surgery group. Multivariate analysis showed emergent operation to be a significant risk factor of DFS (hazard ratio [HR], 3.117; 95% confidence interval [CI], 1.498–6.489; p = 0.002). Conclusions: Preoperative SEMS insertion does not adversely affect long-term oncological outcomes or patient survival.
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U2 - 10.1007/s00384-018-3009-7
DO - 10.1007/s00384-018-3009-7
M3 - Article
C2 - 29532209
AN - SCOPUS:85043453893
VL - 33
SP - 799
EP - 807
JO - International Journal of Colorectal Disease
JF - International Journal of Colorectal Disease
SN - 0179-1958
IS - 6
ER -