Long-term prognosis of short QT interval in Korean patients: a multicenter retrospective cohort study

Dae Young Kim, Jae Sun Uhm, Min Kim, In Soo Kim, Moo Nyun Jin, Hee Tae Yu, Tae Hoon Kim, Jong Youn Kim, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Short QT syndrome is a rare, inherited channelopathy associated with sudden cardiac arrest (SCA) but the characteristics and prognosis of short QT interval (SQTI) in Korean patients remain unclear. This study aimed to determine the clinical characteristics and outcomes of SQTI in a Korean population. Methods: Consecutive patients with SQTI from January 1999 to March 2019 in three university hospitals in South Korea were recruited. SQTI was defined as a Bazett’s formula-corrected QT interval (QTc) ≤ 340 ms in serial electrocardiograms. Age- and sex-matched patients with a normal QTc and without overt cardiovascular disease were included in a 1:4 ratio. Clinical and ECG features and outcomes were compared between patients with and without SQTI. Results: 34 patients with SQTI [age, 23.5 (21–30.5) years; 31 male] were followed up for 4.8 (2.0–7.8) years. Early repolarization, tall T wave, and U wave were significantly more frequent in patients with SQTI than in those without SQTI. QT dispersion [44.0 (28.0–73.0) vs. 20.0 (12.0–35.0) ms, P < 0.001] was significantly wider and heart rate [52.0 (47.0–58.0) vs. 70.0 (62.3–84.0)/min, P < 0.001] was significantly slower in patients with SQTI than in those without. Atrial fibrillation (AF, 11.8% vs. 2.2%, P = 0.030) and ventricular arrhythmia (VA)/SCA (8.7% vs. 0%, P = 0.007) were significantly more frequent in patients with SQTI than in those without. SQTI was significantly associated with AF [odds ratio, 5.911; 95% confidence interval, 1.257–27.808; P = 0.025] and VA/SCA. Conclusions: In this subset of Korean population, SQTI was associated with AF and VA/SCA.

Original languageEnglish
Article number17
JournalBMC Cardiovascular Disorders
Volume21
Issue number1
DOIs
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
The authors thank Ju-young Park, M.S. and Soyoung Jeon, M.S. in the Biostatistics Collaboration Unit, Yonsei University College of Medicine, for their assistance with the statistical analyses and Kina Hu, M.B.A. of GE Healthcare for her assistance with data collection from MUSETMCardiology Information System. We have previously published the abstract of this article in the Heart Rhythm journal on May, 2020?[16].

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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