Long-term progression of retinal vasculitis in Behçet patients using a fluorescein angiography scoring system

Hae Min Kang, Sungchul Lee

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Abstract

Background: To evaluate the long-time progression of retinal vasculitis in Behçet patients using the fluorescein angiography (FA) scoring system. Methods: Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10). Results: Mean number of total active inflammations was 2.6±1.5 times during mean 55.0±20.0 months. Mean scores at the first active inflammation were 1.8±1.0 for optic disc hyperfluorescence, 2.4±1.0 for macular edema, 5.3±2.1 for retinal vascular staining and/or leakage, and 5.8±3.2 for capillary leakage. Mean total FA score was 17.4±6.8. Mean scores at the first quiescent phase were 0.6±0.4 for optic disc hyperfluorescence, 1.1±1.2 for macular edema, 3.8±1.9 for retinal vascular staining and/or leakage, and 3.5±3.5 for capillary leakage. Mean total FA score was 9.1±5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P=0.003 for optic disc hyperfluorescence, P=0.005 for macular leakage, P=0.010 for retinal vascular staining and/or leakage, P=0.008 for capillary leakage, and P=0.018 for total FA score; paired t-test). Conclusions: Retinal vasculitis of Behçet patients did not significantly progress during long-term follow-up.

Original languageEnglish
Pages (from-to)1001-1008
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume252
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Retinal Vasculitis
Fluorescein Angiography
Retinal Vessels
Optic Disk
Macular Edema
Staining and Labeling
Inflammation
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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title = "Long-term progression of retinal vasculitis in Beh{\cc}et patients using a fluorescein angiography scoring system",
abstract = "Background: To evaluate the long-time progression of retinal vasculitis in Beh{\cc}et patients using the fluorescein angiography (FA) scoring system. Methods: Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10). Results: Mean number of total active inflammations was 2.6±1.5 times during mean 55.0±20.0 months. Mean scores at the first active inflammation were 1.8±1.0 for optic disc hyperfluorescence, 2.4±1.0 for macular edema, 5.3±2.1 for retinal vascular staining and/or leakage, and 5.8±3.2 for capillary leakage. Mean total FA score was 17.4±6.8. Mean scores at the first quiescent phase were 0.6±0.4 for optic disc hyperfluorescence, 1.1±1.2 for macular edema, 3.8±1.9 for retinal vascular staining and/or leakage, and 3.5±3.5 for capillary leakage. Mean total FA score was 9.1±5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P=0.003 for optic disc hyperfluorescence, P=0.005 for macular leakage, P=0.010 for retinal vascular staining and/or leakage, P=0.008 for capillary leakage, and P=0.018 for total FA score; paired t-test). Conclusions: Retinal vasculitis of Beh{\cc}et patients did not significantly progress during long-term follow-up.",
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AU - Kang, Hae Min

AU - Lee, Sungchul

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N2 - Background: To evaluate the long-time progression of retinal vasculitis in Behçet patients using the fluorescein angiography (FA) scoring system. Methods: Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10). Results: Mean number of total active inflammations was 2.6±1.5 times during mean 55.0±20.0 months. Mean scores at the first active inflammation were 1.8±1.0 for optic disc hyperfluorescence, 2.4±1.0 for macular edema, 5.3±2.1 for retinal vascular staining and/or leakage, and 5.8±3.2 for capillary leakage. Mean total FA score was 17.4±6.8. Mean scores at the first quiescent phase were 0.6±0.4 for optic disc hyperfluorescence, 1.1±1.2 for macular edema, 3.8±1.9 for retinal vascular staining and/or leakage, and 3.5±3.5 for capillary leakage. Mean total FA score was 9.1±5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P=0.003 for optic disc hyperfluorescence, P=0.005 for macular leakage, P=0.010 for retinal vascular staining and/or leakage, P=0.008 for capillary leakage, and P=0.018 for total FA score; paired t-test). Conclusions: Retinal vasculitis of Behçet patients did not significantly progress during long-term follow-up.

AB - Background: To evaluate the long-time progression of retinal vasculitis in Behçet patients using the fluorescein angiography (FA) scoring system. Methods: Retrospective study was conducted for 71 eyes of 43 patients who met the study criteria. All patients completed at least 2 years of follow-up. FA was taken during the periods of active retinal vasculitis and the quiescent phase, and analyzed using a FA scoring system. Among nine categories, the four most prevalent FA signs were evaluated: optic disc hyperfluorescence (score 0-3), macular edema (score 0-4), retinal vascular staining and/or leakage (score 0-7), and capillary leakage (score 0-10). Results: Mean number of total active inflammations was 2.6±1.5 times during mean 55.0±20.0 months. Mean scores at the first active inflammation were 1.8±1.0 for optic disc hyperfluorescence, 2.4±1.0 for macular edema, 5.3±2.1 for retinal vascular staining and/or leakage, and 5.8±3.2 for capillary leakage. Mean total FA score was 17.4±6.8. Mean scores at the first quiescent phase were 0.6±0.4 for optic disc hyperfluorescence, 1.1±1.2 for macular edema, 3.8±1.9 for retinal vascular staining and/or leakage, and 3.5±3.5 for capillary leakage. Mean total FA score was 9.1±5.0. Mean scores for each active inflammation and quiescent phase were not significantly changed, and mean FA scores were significantly reduced in quiescent phase (P=0.003 for optic disc hyperfluorescence, P=0.005 for macular leakage, P=0.010 for retinal vascular staining and/or leakage, P=0.008 for capillary leakage, and P=0.018 for total FA score; paired t-test). Conclusions: Retinal vasculitis of Behçet patients did not significantly progress during long-term follow-up.

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