Long-term recurrence rates of peptic ulcers without Helicobacter pylori

Jae Hyun Seo, Su Jin Hong, Jie-Hyun Kim, Byung Wook Kim, Sam Ryong Jee, Woo Chul Chung, Ki Nam Shim, Gwang Ho Baik, Sung Soo Kim, Sang Gyun Kim, Jin Il Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, Male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, Male, and comorbid chronic kidney disease.

Original languageEnglish
Pages (from-to)719-725
Number of pages7
JournalGut and liver
Volume10
Issue number5
DOIs
Publication statusPublished - 2016 Sep 1

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Peptic Ulcer
Helicobacter pylori
Recurrence
Chronic Renal Insufficiency
Helicobacter Infections
Korea
Endoscopy
Ulcer

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Seo, J. H., Hong, S. J., Kim, J-H., Kim, B. W., Jee, S. R., Chung, W. C., ... Kim, J. I. (2016). Long-term recurrence rates of peptic ulcers without Helicobacter pylori. Gut and liver, 10(5), 719-725. https://doi.org/10.5009/gnl15262
Seo, Jae Hyun ; Hong, Su Jin ; Kim, Jie-Hyun ; Kim, Byung Wook ; Jee, Sam Ryong ; Chung, Woo Chul ; Shim, Ki Nam ; Baik, Gwang Ho ; Kim, Sung Soo ; Kim, Sang Gyun ; Kim, Jin Il. / Long-term recurrence rates of peptic ulcers without Helicobacter pylori. In: Gut and liver. 2016 ; Vol. 10, No. 5. pp. 719-725.
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abstract = "Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4{\%} in the HP-negative group and 43.8{\%} in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, Male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4{\%} and the factors that affected recurrence were elder, Male, and comorbid chronic kidney disease.",
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Seo, JH, Hong, SJ, Kim, J-H, Kim, BW, Jee, SR, Chung, WC, Shim, KN, Baik, GH, Kim, SS, Kim, SG & Kim, JI 2016, 'Long-term recurrence rates of peptic ulcers without Helicobacter pylori', Gut and liver, vol. 10, no. 5, pp. 719-725. https://doi.org/10.5009/gnl15262

Long-term recurrence rates of peptic ulcers without Helicobacter pylori. / Seo, Jae Hyun; Hong, Su Jin; Kim, Jie-Hyun; Kim, Byung Wook; Jee, Sam Ryong; Chung, Woo Chul; Shim, Ki Nam; Baik, Gwang Ho; Kim, Sung Soo; Kim, Sang Gyun; Kim, Jin Il.

In: Gut and liver, Vol. 10, No. 5, 01.09.2016, p. 719-725.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term recurrence rates of peptic ulcers without Helicobacter pylori

AU - Seo, Jae Hyun

AU - Hong, Su Jin

AU - Kim, Jie-Hyun

AU - Kim, Byung Wook

AU - Jee, Sam Ryong

AU - Chung, Woo Chul

AU - Shim, Ki Nam

AU - Baik, Gwang Ho

AU - Kim, Sung Soo

AU - Kim, Sang Gyun

AU - Kim, Jin Il

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, Male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, Male, and comorbid chronic kidney disease.

AB - Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, Male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, Male, and comorbid chronic kidney disease.

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