Long-term renal safety between patients with chronic hepatitis B receiving tenofovir vs. entecavir therapy: A multicenter study

Young Eun Chon, Soo Young Park, Seung Up Kim, Han Pyo Hong, Jae Seung Lee, Hye Won Lee, Mi Na Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Beom Kyung Kim

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2 Citations (Scopus)


Renal safety is a critical issue in chronic hepatitis B (CHB) patients receiving long-term entecavir (ETV) or tenofovir disofuroxil fumarate (TDF) therapy. We investigated their effects on estimated glomerular filtration rate (eGFR). Treatment-naive CHB patients receiving ETV or TDF for ≥1 year were recruited. The eGFR was assessed using the Chronic Kidney Disease Epidemiology Collaboration equation. We calculated average annual percent change (AAPC) in eGFR using Joinpoint regression. At the beginning of the observation, the ETV group had more unfavorable conditions than the TDF group: lower eGFR and higher FIB-4 and APRI than the TDF group (all p <.001). After 6 years of antiviral therapy, the mean eGFR in the ETV group (n = 1793) was maintained (96.0 at first year to 95.6 ml/min/1.73 m2 at sixth year; AAPC −0.09%; p =.322), whereas that in the TDF group (n = 1240) significantly decreased annually (101.9 at first year to 96.9 ml/min/1.73 m2 at sixth year; AAPC −0.88%; p <.001). Notably, in the TDF group, even patients without diabetes (AAPC −0.80%; p = 0.001) or hypertension (AAPC −0.87%; p =.001) experienced significant decrease in eGFR. Expectably, accompanying diabetes (AAPC −1.59%; p =.011) or hypertension (AAPC −1.00%; p =.002) tended to accelerate eGFR decrease. TDF treatment (odds ratio 1.66, p <.001), along with eGFR<60 ml/min/1.73 m2, serum albumin<3.5 mg/dl, and hypertension, were independently associated with ongoing renal dysfunction, defined as a negative slope of the mean eGFR change. In conclusion, compared with ETV, long-term TDF treatment induced slow, but progressive renal dysfunction. Although the annual eGFR change by TDF was small, careful monitoring is necessary, especially in patients requiring life-long therapy.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalJournal of Viral Hepatitis
Issue number4
Publication statusPublished - 2022 Apr

Bibliographical note

Publisher Copyright:
© 2022 John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases
  • Virology


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