Long-term statin therapy improves oncological outcome after radical gastrectomy for stage II and III gastric cancer

Dong Hyuk Nam, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, SangKil Lee, WooJin Hyung, Yongchan Lee, Min Woong Kang, Sung Hoon Noh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case-control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalAnticancer Research
Volume34
Issue number1
Publication statusPublished - 2014 Jan 1

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Gastrectomy
Stomach Neoplasms
Survival
Therapeutics
Recurrence
Case-Control Studies
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Nam, Dong Hyuk ; Lee, Hyuk ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, SangKil ; Hyung, WooJin ; Lee, Yongchan ; Kang, Min Woong ; Noh, Sung Hoon. / Long-term statin therapy improves oncological outcome after radical gastrectomy for stage II and III gastric cancer. In: Anticancer Research. 2014 ; Vol. 34, No. 1. pp. 355-361.
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abstract = "Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case-control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95{\%} confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95{\%} CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.",
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Long-term statin therapy improves oncological outcome after radical gastrectomy for stage II and III gastric cancer. / Nam, Dong Hyuk; Lee, Hyuk; Park, Jun Chul; Shin, Sung Kwan; Lee, SangKil; Hyung, WooJin; Lee, Yongchan; Kang, Min Woong; Noh, Sung Hoon.

In: Anticancer Research, Vol. 34, No. 1, 01.01.2014, p. 355-361.

Research output: Contribution to journalArticle

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T1 - Long-term statin therapy improves oncological outcome after radical gastrectomy for stage II and III gastric cancer

AU - Nam, Dong Hyuk

AU - Lee, Hyuk

AU - Park, Jun Chul

AU - Shin, Sung Kwan

AU - Lee, SangKil

AU - Hyung, WooJin

AU - Lee, Yongchan

AU - Kang, Min Woong

AU - Noh, Sung Hoon

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N2 - Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case-control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.

AB - Background/Aim: Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. Patiens and Methods: We conducted a matched case-control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009. Results: No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006]. Conclusion: Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.

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