Abstract
The aim of this study was to evaluate the treatment and prognosis of gastric gastrointestinal stromal tumors (GISTs) according to the 7th UICC/AJCC tumor-node-metastasis (TNM) system and the modified National Institutes ofHealth (NIH) risk classification. The study cohort consisted of 1057 patients with gastric GIST who underwent surgery between January 2000 and December 2007 from 13 institutions in Korea and 2 in Japan. Clinicopathologic characteristics, surgical outcomes, recurrence, and 5-year recurrence-free survival were evaluated. The mean age of the patients was 58.6 years. Thirty patients (2.8%) had distant metastasis preoperatively. Median tumor size was 4.0 cm. Complete resection (R0 resection) was achieved in 1018 patients (96.3%). Eighty-six patients (8.1%) had postoperative complications, and 2 patients (0.2%) died within 30 days after surgery. According to the 7th UICC/AJCC TNMsystem, 5-year recurrence-free survival rates were 95% to 99% in stage I, 94.1% in stage II, 74.1% in stage IIIA, 48.6% in stage IIIB, and 50.0% in stage IV patients. On survival analysis of highrisk patients according to the TNM system, the 5-year recurrence-free survival rates were 91.6% in stage II, 74.1% in stage IIIA, and 48.6% in stage IIIB patients. Independent factors of recurrence following surgery for gastric GIST were gender, tumor size, mitotic count, and radicality on multivariate analysis. The treatment outcome and prognosis of gastric GIST in Korea and Japan seem more favorable compared to those in Western countries. Compared to the modified NIH risk classification, the 7th UICC/AJCC TNM system is more reflective of the 5-year recurrence-free survival of patients with gastric GIST.
| Original language | English |
|---|---|
| Article number | e1526 |
| Journal | Medicine (United States) |
| Volume | 94 |
| Issue number | 41 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Long-term surgical outcome of 1057 gastric GISTs according to 7th UICC/AJCC TNM system : Multicenter observational study from Korea and Japan. / Kim, Min Chan; Yook, Jeong Hwan; Yang, Han Kwang; Lee, Hyuk Joon; Sohn, Tae Sung; Hyung, WooJin; Ryu, Seung Wan; Kurokawa, Yukinori; Kim, Young Woo; Han, Sang Uk; Kim, Hyung Ho; Park, Do Joong; Kim, Wook; Lee, Sang Il; Cho, Haruhiko; Cho, Gyu Seok; Kim, Jin Jo; Kim, Ki Han; Yoo, Moon Won.
In: Medicine (United States), Vol. 94, No. 41, e1526, 01.01.2015.Research output: Contribution to journal › Article
TY - JOUR
T1 - Long-term surgical outcome of 1057 gastric GISTs according to 7th UICC/AJCC TNM system
T2 - Multicenter observational study from Korea and Japan
AU - Kim, Min Chan
AU - Yook, Jeong Hwan
AU - Yang, Han Kwang
AU - Lee, Hyuk Joon
AU - Sohn, Tae Sung
AU - Hyung, WooJin
AU - Ryu, Seung Wan
AU - Kurokawa, Yukinori
AU - Kim, Young Woo
AU - Han, Sang Uk
AU - Kim, Hyung Ho
AU - Park, Do Joong
AU - Kim, Wook
AU - Lee, Sang Il
AU - Cho, Haruhiko
AU - Cho, Gyu Seok
AU - Kim, Jin Jo
AU - Kim, Ki Han
AU - Yoo, Moon Won
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The aim of this study was to evaluate the treatment and prognosis of gastric gastrointestinal stromal tumors (GISTs) according to the 7th UICC/AJCC tumor-node-metastasis (TNM) system and the modified National Institutes ofHealth (NIH) risk classification. The study cohort consisted of 1057 patients with gastric GIST who underwent surgery between January 2000 and December 2007 from 13 institutions in Korea and 2 in Japan. Clinicopathologic characteristics, surgical outcomes, recurrence, and 5-year recurrence-free survival were evaluated. The mean age of the patients was 58.6 years. Thirty patients (2.8%) had distant metastasis preoperatively. Median tumor size was 4.0 cm. Complete resection (R0 resection) was achieved in 1018 patients (96.3%). Eighty-six patients (8.1%) had postoperative complications, and 2 patients (0.2%) died within 30 days after surgery. According to the 7th UICC/AJCC TNMsystem, 5-year recurrence-free survival rates were 95% to 99% in stage I, 94.1% in stage II, 74.1% in stage IIIA, 48.6% in stage IIIB, and 50.0% in stage IV patients. On survival analysis of highrisk patients according to the TNM system, the 5-year recurrence-free survival rates were 91.6% in stage II, 74.1% in stage IIIA, and 48.6% in stage IIIB patients. Independent factors of recurrence following surgery for gastric GIST were gender, tumor size, mitotic count, and radicality on multivariate analysis. The treatment outcome and prognosis of gastric GIST in Korea and Japan seem more favorable compared to those in Western countries. Compared to the modified NIH risk classification, the 7th UICC/AJCC TNM system is more reflective of the 5-year recurrence-free survival of patients with gastric GIST.
AB - The aim of this study was to evaluate the treatment and prognosis of gastric gastrointestinal stromal tumors (GISTs) according to the 7th UICC/AJCC tumor-node-metastasis (TNM) system and the modified National Institutes ofHealth (NIH) risk classification. The study cohort consisted of 1057 patients with gastric GIST who underwent surgery between January 2000 and December 2007 from 13 institutions in Korea and 2 in Japan. Clinicopathologic characteristics, surgical outcomes, recurrence, and 5-year recurrence-free survival were evaluated. The mean age of the patients was 58.6 years. Thirty patients (2.8%) had distant metastasis preoperatively. Median tumor size was 4.0 cm. Complete resection (R0 resection) was achieved in 1018 patients (96.3%). Eighty-six patients (8.1%) had postoperative complications, and 2 patients (0.2%) died within 30 days after surgery. According to the 7th UICC/AJCC TNMsystem, 5-year recurrence-free survival rates were 95% to 99% in stage I, 94.1% in stage II, 74.1% in stage IIIA, 48.6% in stage IIIB, and 50.0% in stage IV patients. On survival analysis of highrisk patients according to the TNM system, the 5-year recurrence-free survival rates were 91.6% in stage II, 74.1% in stage IIIA, and 48.6% in stage IIIB patients. Independent factors of recurrence following surgery for gastric GIST were gender, tumor size, mitotic count, and radicality on multivariate analysis. The treatment outcome and prognosis of gastric GIST in Korea and Japan seem more favorable compared to those in Western countries. Compared to the modified NIH risk classification, the 7th UICC/AJCC TNM system is more reflective of the 5-year recurrence-free survival of patients with gastric GIST.
UR - http://www.scopus.com/inward/record.url?scp=84944451917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944451917&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000001526
DO - 10.1097/MD.0000000000001526
M3 - Article
VL - 94
JO - Medicine (United States)
JF - Medicine (United States)
SN - 0025-7974
IS - 41
M1 - e1526
ER -