Importance: There is no consensus on the optimal management of submacular haemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV). Background: To compare the long-term outcome of three treatment strategies for PCV with SMH. Design: Retrospective case series at two tertiary hospitals. Samples: A total of 48 consecutive eyes treated between July 2006 and March 2016. Methods: Patients were grouped according to the treatment received: 22 eyes with intravitreal bevacizumab (IVB), 14 with a combination of IVB and pneumatic displacement (PD) and 12 with IVB and vitrectomy (TPPV). Main Outcome Measures: Change in best-corrected visual acuity (BCVA) at onset and up to 24 months. Secondary measures included demographic data, imaging data and complications. Results: Comparing the mean BCVAs of the groups revealed significant differences only at month 1 (P = 0.005). Changes in the mean BCVA over time revealed no significance in the resulting final BCVA (P = 0.062), which was 20 out of 155 (logMAR 0.89 ± 0.64) for IVB monotherapy, 20 out of 174 (0.94 ± 1.04) for combined IVB + PD, and 20 out of 195 (0.99 ± 0.90) for combined IVB + TPPV eyes. Sustained long-term improvement of over three Snellen lines was found in seven (31.82%) IVB monotherapy, 10 (71.43%) combined IVB + PD, and seven (58.33%) combined IVB + TPPV eyes (P = 0.043). SMH recurrence was observed in two eyes after IVB monotherapy and one eye after combined IVB + PD (P = 0.786). Conclusions and Relevance: IVB monotherapy appears to be as effective as combination therapies for treating SMH secondary to PCV with regards to BCVA at 24 months, and may be a cost-effective strategy for long-term management.
Bibliographical noteFunding Information:
sources: This study was supported by a faculty research grant of Yonsei University College of Medicine (6-2017-0149).The authors wish to acknowledge the essential contributions made by the team of statisticians (H.S.L and S.N.K) from the Yonsei Biomedical Research Institute who helped conduct the analyses in this study.
Funding sources: This study was supported by a faculty research grant of Yonsei University College of Medicine (6-2017-0149).
© 2018 Royal Australian and New Zealand College of Ophthalmologists
All Science Journal Classification (ASJC) codes