Abstract
Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR(-/-) mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism.
| Original language | English |
|---|---|
| Pages (from-to) | 701-712 |
| Number of pages | 12 |
| Journal | Cell |
| Volume | 96 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1999 Mar 5 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Longevity, stress response, and cancer in aging telomerase-deficient mice. / Rudolph, Karl Lenhard; Chang, Sandy; Lee, Han Woong; Blasco, Maria; Gottlieb, Geoffrey J.; Greider, Carol; DePinho, Ronald A.
In: Cell, Vol. 96, No. 5, 05.03.1999, p. 701-712.Research output: Contribution to journal › Article
TY - JOUR
T1 - Longevity, stress response, and cancer in aging telomerase-deficient mice
AU - Rudolph, Karl Lenhard
AU - Chang, Sandy
AU - Lee, Han Woong
AU - Blasco, Maria
AU - Gottlieb, Geoffrey J.
AU - Greider, Carol
AU - DePinho, Ronald A.
PY - 1999/3/5
Y1 - 1999/3/5
N2 - Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR(-/-) mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism.
AB - Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR(-/-) mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism.
UR - http://www.scopus.com/inward/record.url?scp=0033525558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033525558&partnerID=8YFLogxK
U2 - 10.1016/S0092-8674(00)80580-2
DO - 10.1016/S0092-8674(00)80580-2
M3 - Article
C2 - 10089885
AN - SCOPUS:0033525558
VL - 96
SP - 701
EP - 712
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -