Abstract
Background: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. Methods: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. Results: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. Conclusions: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.
| Original language | English |
|---|---|
| Pages (from-to) | 1051-1057 |
| Number of pages | 7 |
| Journal | Acta Neurochirurgica |
| Volume | 157 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2015 Jun 26 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
Cite this
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Longitudinal FDG microPET imaging of neuropathic pain : does cerebellar activity correlate with neuropathic pain development in a rat model? / Kim, Jinhyung; Shin, Jaewoo; Oh, Jin Hwan; Jung, Hyun Ho; Kim, Young Bo; Cho, Zang Hee; Chang, Jin Woo.
In: Acta Neurochirurgica, Vol. 157, No. 6, 26.06.2015, p. 1051-1057.Research output: Contribution to journal › Article
TY - JOUR
T1 - Longitudinal FDG microPET imaging of neuropathic pain
T2 - does cerebellar activity correlate with neuropathic pain development in a rat model?
AU - Kim, Jinhyung
AU - Shin, Jaewoo
AU - Oh, Jin Hwan
AU - Jung, Hyun Ho
AU - Kim, Young Bo
AU - Cho, Zang Hee
AU - Chang, Jin Woo
PY - 2015/6/26
Y1 - 2015/6/26
N2 - Background: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. Methods: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. Results: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. Conclusions: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.
AB - Background: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. Methods: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. Results: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. Conclusions: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.
UR - http://www.scopus.com/inward/record.url?scp=84929711672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929711672&partnerID=8YFLogxK
U2 - 10.1007/s00701-015-2415-7
DO - 10.1007/s00701-015-2415-7
M3 - Article
C2 - 25916400
AN - SCOPUS:84929711672
VL - 157
SP - 1051
EP - 1057
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 6
ER -