Longitudinal tracking of alteration pattern on trabecular bone microarchitecture at tibial epiphysis induced by post traumatic osteoarthritis over time

Joo Hyung Lee, Keyoung Jin Chun, Kwon Young Lee, Dae Jun Kim, Hansung Kim, Dohyung Lim

Research output: Contribution to journalArticle

Abstract

This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (μCT). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T-OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16%, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5-15%, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.

Original languageEnglish
Pages (from-to)1081-1090
Number of pages10
JournalTransactions of the Korean Society of Mechanical Engineers, B
Volume36
Issue number11
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Bone
Ligaments
Tomography
Rats

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

Cite this

@article{b3fb43be386b426db485eaa620590f76,
title = "Longitudinal tracking of alteration pattern on trabecular bone microarchitecture at tibial epiphysis induced by post traumatic osteoarthritis over time",
abstract = "This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (μCT). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T-OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16{\%}, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5-15{\%}, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.",
author = "Lee, {Joo Hyung} and Chun, {Keyoung Jin} and Lee, {Kwon Young} and Kim, {Dae Jun} and Hansung Kim and Dohyung Lim",
year = "2012",
month = "1",
day = "1",
doi = "10.3795/KSME-B.2012.36.11.1081",
language = "English",
volume = "36",
pages = "1081--1090",
journal = "Transactions of the Korean Society of Mechanical Engineers, B",
issn = "1226-4881",
publisher = "Korean Society of Mechanical Engineers",
number = "11",

}

Longitudinal tracking of alteration pattern on trabecular bone microarchitecture at tibial epiphysis induced by post traumatic osteoarthritis over time. / Lee, Joo Hyung; Chun, Keyoung Jin; Lee, Kwon Young; Kim, Dae Jun; Kim, Hansung; Lim, Dohyung.

In: Transactions of the Korean Society of Mechanical Engineers, B, Vol. 36, No. 11, 01.01.2012, p. 1081-1090.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Longitudinal tracking of alteration pattern on trabecular bone microarchitecture at tibial epiphysis induced by post traumatic osteoarthritis over time

AU - Lee, Joo Hyung

AU - Chun, Keyoung Jin

AU - Lee, Kwon Young

AU - Kim, Dae Jun

AU - Kim, Hansung

AU - Lim, Dohyung

PY - 2012/1/1

Y1 - 2012/1/1

N2 - This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (μCT). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T-OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16%, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5-15%, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.

AB - This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (μCT). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T-OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16%, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5-15%, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.

UR - http://www.scopus.com/inward/record.url?scp=84870286908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870286908&partnerID=8YFLogxK

U2 - 10.3795/KSME-B.2012.36.11.1081

DO - 10.3795/KSME-B.2012.36.11.1081

M3 - Article

VL - 36

SP - 1081

EP - 1090

JO - Transactions of the Korean Society of Mechanical Engineers, B

JF - Transactions of the Korean Society of Mechanical Engineers, B

SN - 1226-4881

IS - 11

ER -