Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction

Jinkwon Kim, Dong Hyun Lee, Myoung Jin Cha, Tae Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Jihoe Heo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: The ankle-brachial blood pressure index (ABI) is an established clinical test for assessment of peripheral arterial disease and an indicator of generalized atherosclerosis. We investigated whether low ABI is associated with long-term functional outcome in patients with acute cerebral infarction. Methods: We included 775 patients with acute cerebral infarction who were admitted within 7 days from stroke onset and had completed an ABI measurement during admission. Poor functional outcome was defined as a modified Rankin Scale of more than 2 at three months from stroke onset. The association between low ABI and poor functional outcome was analyzed using logistic regression analysis. Results: A low ABI (<0.9) was present in 10.1% of patients. At three months from stroke onset, 16.9% of patients showed poor functional outcome (mRS > 2). After adjusting for conventional cardiovascular risk factors and the presence of cerebral atherosclerosis, a low ABI was independently associated with poor functional outcome (odds ratio 2.523, 95% CI 1.330-4.785, p = 0.005). Conclusions: The presence of a low ABI was associated with an increased risk of poor functional outcome in patients with acute cerebral infarction. Screening for low ABI among stroke patients may be necessary to identify individuals at increased risk of poor functional outcome. Proper and individualized treatment for patients with a low ABI may improve long-term functional outcome following acute cerebral infarction.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalAtherosclerosis
Volume224
Issue number1
DOIs
Publication statusPublished - 2012 Sep 1

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Ankle Brachial Index
Cerebral Infarction
Ankle
Arm
Blood Pressure
Stroke
Intracranial Arteriosclerosis
Peripheral Arterial Disease
Atherosclerosis
Logistic Models
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Jinkwon ; Lee, Dong Hyun ; Cha, Myoung Jin ; Song, Tae Jin ; Park, Ji Hye ; Lee, Hye Sun ; Nam, Chung Mo ; Nam, Hyo Suk ; Kim, Young Dae ; Heo, Jihoe. / Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction. In: Atherosclerosis. 2012 ; Vol. 224, No. 1. pp. 113-117.
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abstract = "Objective: The ankle-brachial blood pressure index (ABI) is an established clinical test for assessment of peripheral arterial disease and an indicator of generalized atherosclerosis. We investigated whether low ABI is associated with long-term functional outcome in patients with acute cerebral infarction. Methods: We included 775 patients with acute cerebral infarction who were admitted within 7 days from stroke onset and had completed an ABI measurement during admission. Poor functional outcome was defined as a modified Rankin Scale of more than 2 at three months from stroke onset. The association between low ABI and poor functional outcome was analyzed using logistic regression analysis. Results: A low ABI (<0.9) was present in 10.1{\%} of patients. At three months from stroke onset, 16.9{\%} of patients showed poor functional outcome (mRS > 2). After adjusting for conventional cardiovascular risk factors and the presence of cerebral atherosclerosis, a low ABI was independently associated with poor functional outcome (odds ratio 2.523, 95{\%} CI 1.330-4.785, p = 0.005). Conclusions: The presence of a low ABI was associated with an increased risk of poor functional outcome in patients with acute cerebral infarction. Screening for low ABI among stroke patients may be necessary to identify individuals at increased risk of poor functional outcome. Proper and individualized treatment for patients with a low ABI may improve long-term functional outcome following acute cerebral infarction.",
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Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction. / Kim, Jinkwon; Lee, Dong Hyun; Cha, Myoung Jin; Song, Tae Jin; Park, Ji Hye; Lee, Hye Sun; Nam, Chung Mo; Nam, Hyo Suk; Kim, Young Dae; Heo, Jihoe.

In: Atherosclerosis, Vol. 224, No. 1, 01.09.2012, p. 113-117.

Research output: Contribution to journalArticle

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T1 - Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction

AU - Kim, Jinkwon

AU - Lee, Dong Hyun

AU - Cha, Myoung Jin

AU - Song, Tae Jin

AU - Park, Ji Hye

AU - Lee, Hye Sun

AU - Nam, Chung Mo

AU - Nam, Hyo Suk

AU - Kim, Young Dae

AU - Heo, Jihoe

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Objective: The ankle-brachial blood pressure index (ABI) is an established clinical test for assessment of peripheral arterial disease and an indicator of generalized atherosclerosis. We investigated whether low ABI is associated with long-term functional outcome in patients with acute cerebral infarction. Methods: We included 775 patients with acute cerebral infarction who were admitted within 7 days from stroke onset and had completed an ABI measurement during admission. Poor functional outcome was defined as a modified Rankin Scale of more than 2 at three months from stroke onset. The association between low ABI and poor functional outcome was analyzed using logistic regression analysis. Results: A low ABI (<0.9) was present in 10.1% of patients. At three months from stroke onset, 16.9% of patients showed poor functional outcome (mRS > 2). After adjusting for conventional cardiovascular risk factors and the presence of cerebral atherosclerosis, a low ABI was independently associated with poor functional outcome (odds ratio 2.523, 95% CI 1.330-4.785, p = 0.005). Conclusions: The presence of a low ABI was associated with an increased risk of poor functional outcome in patients with acute cerebral infarction. Screening for low ABI among stroke patients may be necessary to identify individuals at increased risk of poor functional outcome. Proper and individualized treatment for patients with a low ABI may improve long-term functional outcome following acute cerebral infarction.

AB - Objective: The ankle-brachial blood pressure index (ABI) is an established clinical test for assessment of peripheral arterial disease and an indicator of generalized atherosclerosis. We investigated whether low ABI is associated with long-term functional outcome in patients with acute cerebral infarction. Methods: We included 775 patients with acute cerebral infarction who were admitted within 7 days from stroke onset and had completed an ABI measurement during admission. Poor functional outcome was defined as a modified Rankin Scale of more than 2 at three months from stroke onset. The association between low ABI and poor functional outcome was analyzed using logistic regression analysis. Results: A low ABI (<0.9) was present in 10.1% of patients. At three months from stroke onset, 16.9% of patients showed poor functional outcome (mRS > 2). After adjusting for conventional cardiovascular risk factors and the presence of cerebral atherosclerosis, a low ABI was independently associated with poor functional outcome (odds ratio 2.523, 95% CI 1.330-4.785, p = 0.005). Conclusions: The presence of a low ABI was associated with an increased risk of poor functional outcome in patients with acute cerebral infarction. Screening for low ABI among stroke patients may be necessary to identify individuals at increased risk of poor functional outcome. Proper and individualized treatment for patients with a low ABI may improve long-term functional outcome following acute cerebral infarction.

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