Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients

Dong Eun Yoo, Mi Jung Lee, Hyung Jung Oh, Seung Jun Kim, Dong Ho Shin, TaeHyun Yoo, Shin-Wook Kang, Kyu Hun Choi, Dae Suk Han, SeungHyeok Han

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m2. IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/ m 2 . When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR >1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD.

Original languageEnglish
Pages (from-to)685-695
Number of pages11
JournalEndocrine Journal
Volume59
Issue number8
DOIs
Publication statusPublished - 2012 Oct 31

Fingerprint

Adiponectin
Peritoneal Dialysis
Insulin Resistance
Resistin
Leptin
Adipokines
C-Reactive Protein
Chronic Kidney Failure
Linear Models
Body Mass Index
Serum
HDL Cholesterol
Interleukin-6
Triglycerides
Obesity
Cross-Sectional Studies
Kidney

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Yoo, Dong Eun ; Lee, Mi Jung ; Oh, Hyung Jung ; Kim, Seung Jun ; Shin, Dong Ho ; Yoo, TaeHyun ; Kang, Shin-Wook ; Choi, Kyu Hun ; Han, Dae Suk ; Han, SeungHyeok. / Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. In: Endocrine Journal. 2012 ; Vol. 59, No. 8. pp. 685-695.
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abstract = "In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m2. IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/ m 2 . When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR >1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD.",
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Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. / Yoo, Dong Eun; Lee, Mi Jung; Oh, Hyung Jung; Kim, Seung Jun; Shin, Dong Ho; Yoo, TaeHyun; Kang, Shin-Wook; Choi, Kyu Hun; Han, Dae Suk; Han, SeungHyeok.

In: Endocrine Journal, Vol. 59, No. 8, 31.10.2012, p. 685-695.

Research output: Contribution to journalArticle

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T1 - Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients

AU - Yoo, Dong Eun

AU - Lee, Mi Jung

AU - Oh, Hyung Jung

AU - Kim, Seung Jun

AU - Shin, Dong Ho

AU - Yoo, TaeHyun

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

AU - Han, Dae Suk

AU - Han, SeungHyeok

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