Low-cost label-free electrical detection of artificial DNA nanostructures using solution-processed oxide thin-film transistors

Si Joon Kim, Joohye Jung, Keun Woo Lee, Doo Hyun Yoon, Tae Soo Jung, Sreekantha Reddy Dugasani, Sung Ha Park, Hyun Jae Kim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A high-sensitivity, label-free method for detecting deoxyribonucleic acid (DNA) using solution-processed oxide thin-film transistors (TFTs) was developed. Double-crossover (DX) DNA nanostructures with different concentrations of divalent Cu ion (Cu2+) were immobilized on an In-Ga-Zn-O (IGZO) back-channel surface, which changed the electrical performance of the IGZO TFTs. The detection mechanism of the IGZO TFT-based DNA biosensor is attributed to electron trapping and electrostatic interactions caused by negatively charged phosphate groups on the DNA backbone. Furthermore, Cu2+ in DX DNA nanostructures generates a current path when a gate bias is applied. The direct effect on the electrical response implies that solution-processed IGZO TFTs could be used to realize low-cost and high-sensitivity DNA biosensors.

Original languageEnglish
Pages (from-to)10715-10720
Number of pages6
JournalACS Applied Materials and Interfaces
Volume5
Issue number21
DOIs
Publication statusPublished - 2013 Nov 13

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Thin film transistors
Oxide films
Labels
Nanostructures
DNA
Costs
Biosensors
Coulomb interactions
Phosphates
Ions
Electrons

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Kim, Si Joon ; Jung, Joohye ; Lee, Keun Woo ; Yoon, Doo Hyun ; Jung, Tae Soo ; Dugasani, Sreekantha Reddy ; Park, Sung Ha ; Kim, Hyun Jae. / Low-cost label-free electrical detection of artificial DNA nanostructures using solution-processed oxide thin-film transistors. In: ACS Applied Materials and Interfaces. 2013 ; Vol. 5, No. 21. pp. 10715-10720.
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abstract = "A high-sensitivity, label-free method for detecting deoxyribonucleic acid (DNA) using solution-processed oxide thin-film transistors (TFTs) was developed. Double-crossover (DX) DNA nanostructures with different concentrations of divalent Cu ion (Cu2+) were immobilized on an In-Ga-Zn-O (IGZO) back-channel surface, which changed the electrical performance of the IGZO TFTs. The detection mechanism of the IGZO TFT-based DNA biosensor is attributed to electron trapping and electrostatic interactions caused by negatively charged phosphate groups on the DNA backbone. Furthermore, Cu2+ in DX DNA nanostructures generates a current path when a gate bias is applied. The direct effect on the electrical response implies that solution-processed IGZO TFTs could be used to realize low-cost and high-sensitivity DNA biosensors.",
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Low-cost label-free electrical detection of artificial DNA nanostructures using solution-processed oxide thin-film transistors. / Kim, Si Joon; Jung, Joohye; Lee, Keun Woo; Yoon, Doo Hyun; Jung, Tae Soo; Dugasani, Sreekantha Reddy; Park, Sung Ha; Kim, Hyun Jae.

In: ACS Applied Materials and Interfaces, Vol. 5, No. 21, 13.11.2013, p. 10715-10720.

Research output: Contribution to journalArticle

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