Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients

Chang Yun Yoon, Jimin Park, Changhwan Seo, Bo Young Nam, Seonghun Kim, Youn Kyung Kee, Misol Lee, Min Uk Cha, Hyoungnae Kim, Seohyun Park, Hae Ryong Yun, Su Young Jung, Jong Hyun Jhee, Young Eun Kwon, Meiyan Wu, Jae Eun Um, Hye Young Kang, Jung Tak Park, Seung Hyeok Han, Shin Wook KangHyeon Chang Kim, Sungha Park, Sung Kil Lim, Tae Hyun Yoo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1 ± 11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio = 0.719; 95% confidence interval [CI] 0.522–0.989; p = 0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p = 0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio = 0.855; 95% CI 0.743–0.984; p = 0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients.

Original languageEnglish
Pages (from-to)2149-2158
Number of pages10
JournalJournal of Bone and Mineral Research
Volume31
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Peritoneal Dialysis
Dentin
Proteins
Vascular Calcification
Osteocytes
Indican
Dialysis
Confidence Intervals
Chronic Kidney Disease-Mineral and Bone Disorder

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Yoon, Chang Yun ; Park, Jimin ; Seo, Changhwan ; Nam, Bo Young ; Kim, Seonghun ; Kee, Youn Kyung ; Lee, Misol ; Cha, Min Uk ; Kim, Hyoungnae ; Park, Seohyun ; Yun, Hae Ryong ; Jung, Su Young ; Jhee, Jong Hyun ; Kwon, Young Eun ; Wu, Meiyan ; Um, Jae Eun ; Kang, Hye Young ; Park, Jung Tak ; Han, Seung Hyeok ; Kang, Shin Wook ; Kim, Hyeon Chang ; Park, Sungha ; Lim, Sung Kil ; Yoo, Tae Hyun. / Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients. In: Journal of Bone and Mineral Research. 2016 ; Vol. 31, No. 12. pp. 2149-2158.
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abstract = "Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1 ± 11.8 years, and 116 (52.0{\%}) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio = 0.719; 95{\%} confidence interval [CI] 0.522–0.989; p = 0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4{\%}) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p = 0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio = 0.855; 95{\%} CI 0.743–0.984; p = 0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients.",
author = "Yoon, {Chang Yun} and Jimin Park and Changhwan Seo and Nam, {Bo Young} and Seonghun Kim and Kee, {Youn Kyung} and Misol Lee and Cha, {Min Uk} and Hyoungnae Kim and Seohyun Park and Yun, {Hae Ryong} and Jung, {Su Young} and Jhee, {Jong Hyun} and Kwon, {Young Eun} and Meiyan Wu and Um, {Jae Eun} and Kang, {Hye Young} and Park, {Jung Tak} and Han, {Seung Hyeok} and Kang, {Shin Wook} and Kim, {Hyeon Chang} and Sungha Park and Lim, {Sung Kil} and Yoo, {Tae Hyun}",
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Yoon, CY, Park, J, Seo, C, Nam, BY, Kim, S, Kee, YK, Lee, M, Cha, MU, Kim, H, Park, S, Yun, HR, Jung, SY, Jhee, JH, Kwon, YE, Wu, M, Um, JE, Kang, HY, Park, JT, Han, SH, Kang, SW, Kim, HC, Park, S, Lim, SK & Yoo, TH 2016, 'Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients', Journal of Bone and Mineral Research, vol. 31, no. 12, pp. 2149-2158. https://doi.org/10.1002/jbmr.2907

Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients. / Yoon, Chang Yun; Park, Jimin; Seo, Changhwan; Nam, Bo Young; Kim, Seonghun; Kee, Youn Kyung; Lee, Misol; Cha, Min Uk; Kim, Hyoungnae; Park, Seohyun; Yun, Hae Ryong; Jung, Su Young; Jhee, Jong Hyun; Kwon, Young Eun; Wu, Meiyan; Um, Jae Eun; Kang, Hye Young; Park, Jung Tak; Han, Seung Hyeok; Kang, Shin Wook; Kim, Hyeon Chang; Park, Sungha; Lim, Sung Kil; Yoo, Tae Hyun.

In: Journal of Bone and Mineral Research, Vol. 31, No. 12, 01.12.2016, p. 2149-2158.

Research output: Contribution to journalArticle

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T1 - Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients

AU - Yoon, Chang Yun

AU - Park, Jimin

AU - Seo, Changhwan

AU - Nam, Bo Young

AU - Kim, Seonghun

AU - Kee, Youn Kyung

AU - Lee, Misol

AU - Cha, Min Uk

AU - Kim, Hyoungnae

AU - Park, Seohyun

AU - Yun, Hae Ryong

AU - Jung, Su Young

AU - Jhee, Jong Hyun

AU - Kwon, Young Eun

AU - Wu, Meiyan

AU - Um, Jae Eun

AU - Kang, Hye Young

AU - Park, Jung Tak

AU - Han, Seung Hyeok

AU - Kang, Shin Wook

AU - Kim, Hyeon Chang

AU - Park, Sungha

AU - Lim, Sung Kil

AU - Yoo, Tae Hyun

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1 ± 11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio = 0.719; 95% confidence interval [CI] 0.522–0.989; p = 0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p = 0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio = 0.855; 95% CI 0.743–0.984; p = 0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients.

AB - Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1 ± 11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio = 0.719; 95% confidence interval [CI] 0.522–0.989; p = 0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p = 0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio = 0.855; 95% CI 0.743–0.984; p = 0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients.

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